Factor def. Anemias Flashcards

1
Q

factor def. anemias are a result of

A

lack of available the raw materials necessary for the process of hematopoiesis
not usually a dietary lack so much as a demand need

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2
Q

factors necessary for Hb synthesis

A

iron
B12
folic acid
pyridoxine

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3
Q

cells smaller than normal
Hb molecule defect due to a lack of iron
most common cause is iron def. (IDA)

A

microcytosis

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4
Q

in microcytosis:
MCV ____
MCHC ____

A

MCV: decreases
MCHC: decreases

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5
Q

as microcytosis evolves over time…

A

serum ferritin: decreases
microcytosis
hypochromia

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6
Q

SI___/TIBC___:

normal, hemochromatosis, iron overload, pyridoxine def. or other sideroblastic anemias, hemolysis

A

SI: increased
TIBC: decreased

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7
Q

SI____/TIBC___:

chronic IDA, later pregnancy

A

SI: decreased
TIBC: increased

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8
Q

SI___/TIBC___:

BCPs, hepatitis

A

SI: increased
TIBC: increased

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9
Q

SI____/TIBC____:

chronic dz, uremia

A

SI: decreased
TIBC: decreased

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10
Q

necessary for the development of heme

decreased by meds, alcohol, stress, diet

A

pyridoxine

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11
Q

PD in SI ______ and TIBC _____

A

SI: increased
TIBC: decreased

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12
Q

cells larger than normal
due to def. of B12 or folic acid
megaloblastic changes

A

macrocytosis

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13
Q

found in foods of animal origin: dairy, meat, and egg products

A

cyanocobalamin

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14
Q

def. develops from
inability to absorb due to lack of intrinsic factor
autoimmune antibodies damage parietal and chief cells
lack of gastric acid
malabsorption syndromes involving the terminal ileum
surgery of distal small intestine

A

macrocytosis

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15
Q

macrocytosis: dietary def. are _____ and found mainly in strict vegetarians

A

RARE

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16
Q

in macrocytosis:
MCV ____
MCHC ____

A

MCV: increased over 100
MCHC: normal

17
Q

T/F: serum B12 should be low but can be falsely elevated in macrocytosis

A

TRUE

18
Q

diagnostic test for macrocytosis

A

shilling test

19
Q

def cause similar changes to the cellular picture of macrocytosis

A

folic acid