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Flashcards in Feline Viral infection Deck (24)
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Feline viruses. Name:
Feline Respiratory viruses
Panleucopenia virus
and others

• Respiratory viruses – FCV and FeHV-1
• Retroviruses – Feline Leukaemia Virus and Feline Immunodeficiency Virus
• Coronavirus – FECoV and Feline Infectious Peritonitis V
• Panleucopenia – SMALL DNA VIRUS but lodt DNA polymerase so needs host
• Others = cowpox, influenza virus, Bornavirus
o Rabies (see dog lecture)


Feline Panleucopenia names

Lots of different names including:
• Feline Infectious enteritis
• Feline parvovirus
• Canine parvovirus


IS feline panleucopnia rare or common?

• Relatively rare disease as Successful vaccination
It is a parvovirus so not enveloped, stable adn ** survives a long time in the environment **


PAthogenesis of feline panleucopnia virus

1. As FPLV is a DNA virus with NO polymerase it targets cells with lots
2. Targets actively dividing cells - polymerase
= Epithelium (enteritis)
Bone marrow and lymphoid tissue
= Late gestation, neonatal cerebellum = cerebellar hypoplasia
In early pregnancy = foetal death, abortion


Clinical signs of feline panleucopenia

• Sudden death
• Intestinal Profuse diarrhoea, often vomiting too
• Pyrexia, depression, anorexia basically go into shock and die
• Cerebellar hypoplasia – wobble, can’t control fine muscle movement
• Vvvvv sick, depressed, dehydrated kitten


What does panleucopenia mean?

pan = all – leuc = WBC openia = not enough


Treatment of panleucopnia

• Interferon (not licensed cats but used, lisenced in dogs)
• Fluid therapy – as animals die of shock so this is huge!
• Antibacterial to control secondary infection (sepsis)
- WILL die if untreated


What other diseases is interferon used to treat?

1. FPLV (feline panleucopnia virus)
2. Feline leukaemia virus
3. FIP (not credited but some info on)


How to diagnose feline

• Clinical signs and history (no vaccination in 99% cases)
• Post-mortem examination – histopathology
• Serology (unless vaccinated – Antibodies, not desperately helpful as could be MDA or vaccine)
• Faecal samples for identification of virus
• PCR now


How to prevent feline panleucopnia

• Vaccination – live and inactivated
• Biosecurity – closure of kennel/cattery etc
• Elimination of virus from environment


Other feline enteric viruses

• Feline enteric coronavirus (mutates to FIPV)
o Feline astrovirus
o Feline rotavirus (much rarer than in cows and sheep)
o Feline torovirus
 Has been associated with syndrome of diarrhoea and protruding third eyelid (but controversial) – no treatment, cats recover

Don't need to know this


Cow pox in cats
- what is the reservoir host?
- what time of yr seen?
- what drug to avoid?

• Reservoir hosts are small wild mammals
• Disease is mostly seen in rural hunting cats
• Most cases are seen in summer and autumn – rodent availability
• Typically starts with a single primary lesion,  bitten
• Widespread secondary skin lesions often develop after 1 to 3 weeks
o most animals recover uneventfully
o Occasionally, especially in immunosuppressed cats, systemic illness may develop


Influenza virus H5N1 importance

Rare in cats but still notifiable as can kill humans although no present evidence cat to human
We think of influenza as a respiratory disease but in cats enteric


Domestic cats adn influenza
where from?
clincial signs

1. infected by contact with domestic or wild birds and possibly their droppings
2. develop severe to fatal disease
o raised body temperature
o decreased activity
o conjunctivitis and
o laboured breathing


Where do cats shed influenza virus?

respiratory and digestive tracts
• transmit the infection to other cats. CAT TO CAT
• We think of influenza as a respiratory disease but in cats enteric


Why don't you use X when treating cat with influenza?

This suppresses the cats immune system further - can become systemically ill.
Keep infected cat indoor


Feline spongiform encephalopathy (FSE)

• Prion protein disease
• Same agent as BSE in cattle


CLincial signs of Feline spongiform encephalopathy in cats

• Behavioural changes, polyphagia, polydipsia, altered grooming habits, muscle fasiculations, drooling of saliva, altered gait


What are the core vaccines for cats?
when given?

FPV, FCV and FHV-1.
Feline panleucopnia
Feline Calici virus
Feline herpes virus
for initial vaccination at 8–9 weeks of age followed by a second vaccination 3–4 weeks later, and if necessary a third vaccination given between 14–16 weeks of age. Boost at one year, then every three.
o 9 weeks, 12 weeks, 15,


Core vaccinations for dogs

CDV, CAV and CPV-2.
Canine distemper virus
Canine adenovirus
Canine parvovirus

for initial vaccination at 8–9 weeks of age followed by a second vaccination 3–4 weeks later, and if necessary a third vaccination given between 14–16 weeks of age. Boost at one year, then every three (yr 4, 7, 10)
o 9 weeks, 12 weeks, 15,


What are the feline non core vaccines?
When should they be given?

FeLV, CPiV, Bb, CCoV, CIV, Lepto
(Feline leukaemia, Canine Parainfluenza Virus, Feline bordetellosis, canine coronavirus)

Annually as believed to have shorter duration


What does efficacy of vaccine depedn on?

1. Efficacy of kitten vaccination depends on MDA which dependent on titre in dam and ingestion colostrum


What about vaccinating pregnant queens?

• Avoid live vaccines in pregnant queens due to panlucopemia (likes to divide in rapidly dividing cells – fetus


Problems with vaccine?

• Occasional lack of efficacy
• Occasional adverse reactions
o Injection site sarcomas
• Post-licensing
o surveillance scheme