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Flashcards in Final Deck (50)
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1

A patient with simultaneous strong elevations of urinary citrate, cis-aconitate, isocitrate and orotate is also likely to be exhibiting which other laboratory abnormality?

Ammonemia

2

Elevation of which compound indicates that inflammatory responses are occurring in the brain?

Quinolinic acid

3

Why would dietary protein intake not be expected to produce elevated levels of amino acids in plasma when the test is done according to usual specimen colection instructions?

After more than six hours, amino acids from dietary protein do not affect peripheral blood amino acid concentrations.

4

A patient with signs consistent with magnesium deficiency that is confirmed by low erythrocyte magnesium is likely to have low status of what other compound with direct effects on magnesium status?

glutathione

5

A patient who had a lab result showing high urinary tricarballylate would be a candidate for which nutrient supplementation?

magnesium

6

Insufficiency of which hormone is associated with impaired conversion of beta carotene to vitamin A?

thyroid

7

When a patient is found to have high levels of LA and GLA, but a low level of DGLA on a plasma fatty acid profile, what specific nutrient intervention is suggested?

zinc

8

Folic acid supplementation is indicated when a LOW result is found for which laboratory test?

plasma histidine

9

Which specific nutrient supplementation is most directly indicated for a patient with a greatly elevated plasma phenylalanine to tyrosine ratio?

iron

10

Which specific nutrient supplementation is most directly indicated for a patient with greatly elevated serum levels of citrulline and ornithine?

magnesium

11

Increased intake of which nutrient is most specifically indicated for a patient with hyperinsulinemia?

chromium

12

When glutathione becomes oxidized in a reaction that removes an oxygen radical, which compound is the co-substrate for the conversion back to reduced glutathione?

NADPH

13

A patient with a low serum transferrin level is a candidate for supplementation of which nutrient?

Iron

14

Aggressive biotin supplementation would be indicated for a patient with which abnormality?

High urinary beta-hydroxyisovalerate

15

Concurrent elevations of urinary L-lactate and pyruvate have been shown to respond favorably to which vitamin supplementation?

lipoic acid

16

Your patient reveals that s/he has been supplementing with high doses of fish oil for years and always cooks with safflower oil and corn oil. Based on this information, what analyte(s) would you suspect might be elevated?

lipid peroxides

17

What compound is a precursor in human cells for tetrahydrobiopterin production?

GTP

18

A patient whose diet contains very low levels of polyphenols may have false negative results for which test?

urinary microbial markers

19

What condition is revealed by finding a large number of 2+ to 4+ results for food-specific IgG4 concentrations in serum?

Intestinal hyperpermeability

20

Measuring breath hydrogen after an oral bolus of glucose is a test used to detect which condition?

transitional gut bacterial overgrowth

21

Why do microbiological culture techniques performed in routine clinical laboratory services fail to detect the large majority of bacteria that occur in stool specimens?

the bacteria are strict anaerobes

22

Which food-specific serum antibody class is tested primarily to determine the presence of intestinal hyperpermeability?

IgG

23

What region of the normal human intestinal tract has the greatest rate of increase in bacteria populations per inch of transit?

ileum

24

Which laboratory abnormality would be the most ominous as a risk factor for a chronic pain patient who has a tendency to overdose her acetaminophen?

low plasma methionine

25

Which compound has the unique function of being simultaneously required for the activated methyl-supply system and the glutathione-formation system?

homocysteine

26

If glycine is to be administered to support Phase II detoxification, what vitamin also is specifically indicated?

pantothenic acid (B5)

27

Which component of biological membranes is most highly susceptible to hydroxyl radical attack?

PUFAs

28

What vitamin-derived enzyme cofactor contains pantothenic acid?

Coenzyme A

29

Which antioxidant is found in erythrocytes at levels nearly 10 times those found in blood plasma?

taurine

30

A defect in which regulatory system is indicated by finding the pattern of very high glutamic acid and very low glutamine in a plasma amino acid profile for a 4 year old boy with severe hyperactivity?

SN1-SN2 transporter