Final Exam--Equine

Question 1

In horses PPID is most commonly due to?

How does it happen?

Answer 1

an adenoma of pars intermedia

a loss of dopaminergic innervation of pars intermedia may cause tumor to grow

Question 2

Which test is considered the gold standard for diagnosing PPID?

Answer 2

Low dose dex suppression

Question 3

If you’re worried about dex causing a horse to develop laminitis, what is another good test for PPID?

Answer 3

TRH-ACTH response

Question 4

Which drug is FDA approved for treatment of PPID in horses? What is it’s MOA?

Answer 4

Pergolide

Dopamine agonist (works to inhibit POMC release from pars intermedia)

Question 5

Cyproheptidate is another tx option for PPID in horses. How does it work?

Answer 5

serotoning antagonist

*serotonin stimulates secretion of POMCs

Question 6

Which medication is indicated for short-term use in EMS horses that show weight loss resistance?

Answer 6

Levothyroxine