Final Exam (Pulmonary HT)

Question 1

Epoprostenol (synthetic PGI2)

Answer 1

• Tx of pulmonary arterial HT
• MOA: activates Gs, increases cAMP, activates PKA, PKA phosphorylates MLCK decreasing its activity, results in dephosphorylation of MLC of myosin, muscle relaxation leads to vasodilation

Question 2

Bosentan

Answer 2

nonselective endothelin (ET) ETa & ETb receptor antagonist
-Normally ET-1 binds to ETa and increases NO.  Blocking this would have the opposite effect of vasodilation

Question 3

Ambrisentan

Answer 3

• Tx of pulmonary HT

- selective ETa receptor antagonist

Question 4

Sildenafil, Tadalafil, Vardenafil

Answer 4

-Tx of pulmonary HT
PDE-5 antagonists
-inhibits breakdown of cGMP
-lowers intracellular [Ca+2] in smooth muscle cell leading to less contraction, relaxation, and vasodilation

Question 5

Riociguat

Answer 5

• Tx pulmonary HT
• soluble guanylate cyclase activator
• good for cases of damaged endothelium