Flashcards in Final Final Review Deck (49)
AE of Glitazone (TZDs)?
AE - FLUID RETENTION, weight gain, edema, exacerbates CSF, contraindicated in pts with class III and IV heart failure, MONITOR LIVER FUNCTIONING
Effect of mercury?
Mercury reacts with -SH groups in vivo inhibiting enzymes and altering cell membranes.
2nd line agent for GAD
-partial 5-HT1a agonist
-gradual onset of 2 weeks
-no abuse potential
-no withdrawal reaciton
-no alcohol potentiation
-no sedative-hypnotic effect
AE of amantadine?
Livedo reticularis [purple, mottled skin]
How do you treat anorexia in end of life care?
Action of acamprosate?
AE of tubocurarine?
**all of this is b/c it is Benzylisoquinolines which causes massive histamine release -- DO NOT GIVE TO PATIENT WITH ASTHMA
How are ester anesthetics metabolized?
Via esterases - extrahepatically
What is morphine used for in end of life care?
Pain and dyspnea
Other than anesthetic property, what else does propofol provide?
Phenobarbital analog used for ESSENTIAL TREMOR
AE - QT prolongation
ER antagonist everywhere in the body used to treat estrogen receptive breast cancer that is unresponsive to other treatment
Levothyroxine vs Liothyronine?
Levothyroxine: T4, longer half-life
Liothyronine: T3, 10x more potent
What receptor does oxytocin bind to?
Tx theophylline-induced seizures?
Benzos and barbiturates
Pt has thyroid storm but has history of asthma?
Give CCB NOT B-blockers -- aka give diltiazem and verapamil
Partial agonist at androgen receptors
Tx endometriosis and fibrocystic disease of the breast
AE - acne, weight gain, hepatotoxicity, decrease HDL
Indirect-acting sympathomimetic that enhances catecholamine release from presynaptic neuron
Organophosphate that binds ACHE inhibiting it -- reverse with pralidoxime or Atropine
Which SSRIs have the lowest potential for drug interactions?
Citalopram, escitalopram and sertraline
*fluoxetine, paroxetine and Fluvoxamine have lots of CYP interactions
AE of Clozapine?
Agranulocytosis [continue to do blood draws]
Which insomnia medication has the least day after drowsiness?
partial mu agonist and kappa antagonist used to treat opioid addiction
pink discoloration of hands and feet due to exposure to heavy metals such as mercury -- treat with acute (DUS) and chronic (US)
Which corticosteroids do not have any mineralocorticoid activity?
Dexamethasone and Triamcinolone
Antidote for non-depolarizing ACh blockers?
Endrophonium and Neostigmine
Atypical antipsychotic that is a PARTIAL agonist at D2 receptor -- all other atypical antipsychotics are competitive antagonists
-vit B12 deficiency
Which TCAs have less anticholinergic effects?
secondary amines - Desipramine and Nortryptilline