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Flashcards in Finals - transfusion reaction Deck (42):
1

(T/F) Blood transfusion is a permanent treatment

false

temporary

2

____ any adverse response by the recipient during or after transfusion of blood or blood products, some are preventable

transfusion reaction

3

_____ classification of transfusion reactions

immune and non-immune (immediate or delayed)

4

____ is when Signs and symptoms occur during the transfusion or within 24 hours after, by antibodies already present in the recipient’s circulation

Immediate/Acute non-immune TR

5

____ what do the ff stand for: TRIALI, TACO

Transfusion Related Acute Lung Injury
Transfusion Associated Circulatory Overload

6

which of the ff transfusion related fatalities is the most common occurrence in the past years?
a. HTR-ABO
b. HTR - non ABO
c. TRIALI
d. anaphylaxis

C

43% of fatalities in 2010
33% in 2011

7

(T/F) HTR-ABO fatalities is the lowest among transfusion related fatalities

true

~ 3-11%

8

____ when RBCs are rapidly destroyed and its products are released into the circulation

intravascular hemolysis (in IHTR)

9

___ list the the signs of IHTR (7)

Hemoglobinuria
Abnormal bleeding at the surgical site
Hypotension
unconsciousness (?)
fever
pain
increased heart rate

more on pg 23, lec 10

10

___ list the possible outcomes of IHTR (3)

Shock
Acute renal failure
Disseminated intravascular coagulation (DIC)

11

____ list the antibodies (abs) most commonly implicated in IHTR

Anti-A
Anti-K
Anti-Jka
Anti-Fya

12

(T/F) the abs involved in IHTR does not activate complement

false

it can!!!!

13

which of the ff is the antibody that is the most common culprit in IHTRs?
a. Anti-A
b. Anti-K
c. Anti-Jka
d. Anti-Fya

A

42%

14

(T/F)immune mediated hemolysis of RBCs are initiated by the primary exposure of patient to incompatible RBCs

false

2ndary - when Ag-Ab (incompatible rbc - patient ab) complexes form

15

(T/F) in intravascular HTR, Complement is INcompletely activated and NO free hemoglobin, RBC enzymes or RBC stroma are released into the circulation

false

this is for extravascular

16

___ these cells are involved in extravascular IHTR

macrophages

17

____ the immediate action when signs of transfusion rxn is observed

STOP THE TRANSFUSION

18

____ treatment for acute renal failure in IHTR to induce kidney function and diuresis

furosemide

19

(T/F) treatments for extravascular IHTR are also needed

F

therapy not needed (kay wala may products na irelease sa plasma ?)

20

___ list the sources of error for IHTR

incorrect:
Identification of recipient
Sample collection and labeling
Donor unit identification
Patient testing

21

(T/F) intravascular hemolysis also usually occurs in DELAYED HTRs

false

usually extravascular

22

(T/F) DHTR is usually because patient was sensitized before by transplant, transfusion, pregnancy

true

23

which of the ff is false about DHTR?
a. mixed field agglutination is usually seen
b. Liver failure is involved
c. signs usually seen in anamnestic response
d. usually DAT neg

D

3 – 7 days after trans the direct antiglobulin test (DAT) is posi.ve with a mixed field pattern of agglutination

24

(T/F) in DHTR,

true

25

which of the ff is false about DHTR?
a. c3d may be present on the RBCs
b. typically do not bind complement
c. is detected serologically
d. symptoms are more severe than IHTR

D

milder symptoms

26

___ Anamnestic response in DHTR that does not result in
hemolysis

delayed serologic transfusion
reaction (DSTR)

27

___ most common sign in DHTR

mild fever with/without chills

28

__ list the ab involved in DHTR

Rh antibodies (mainly −c, −E & −C)
Kidd abs (Jka most often implicated)
Duffy abs (Fy)
K abs

29

___ list the signs of DHTR

DAT pos
mild fever with/without chills
Moderate jaundice

30

__ a 1⁰C increase in temperature associated with transfusion, may involve chills and rigor

Febrile Nonhemolytic Transfusion Reaction (FNHTR)

31

which of the ff is false about FNHTR?
a. caused by HLA antibodies
b. can be prevented by antipyretics
c. can be stimulated by tissue transplantation
d. pyrogens are involved

all are true :)

32

(T/F) FNHTR involves C5a complement activation

true

33

___ preventative measure for FNHTR

Leukocyte reduced blood
Pre-medicate the pa.ent with antipyretics

34

___ an allergic transfusion reaction

Anaphylactic Transfusion Reactions

35

which of the ff is false about Anaphylactic Transfusion Reactions?
a. involves fever
b. signs appear after exposure to few ml of plasma or blood products
c. can cause shock and death
d.associated with IgA

A

no fever

36

____ list the signs and symptoms of TRALI

*pulmonary edema
*Chills, Fever
*Hypotension
Dyspnea
Cyanosis
Tachycardia
Hypoxemia

37

which of the ff about TRALI is false?
a. main cause: passive transfer of HLA to recepient
b. recipient has WBC abs that react with donor transfused WBC antigens
c. Blood components containing plasma are
always involved
d. symptoms are immediate


all is true :)

38

(T/F) male only plasma transfusion is used as a preventative measure for TRALI

true

39

___ list the bacteria involved in transfusion reactions

- Yersinia enterocolitica
– Serra-a liquefaciens
– Psuedomonas fluorescens

40

(T/F) gram positive bacteria involved in bacterial contamination of blood can survive in 4C

false first part

G- only!

41

(T/F) bacterial contamination in platelets are mostly by G+ organisms

true

Staphylococcus spp.
Bacillus cereus

42

___ list other possible causes of TRs

Physically or Chemically Induced TRs
Transfusion-Associated Circulatory Overload
(TACO)
Post-Transfusion Purpura (PTP)
Transfusion-Associated Graft-versus Host
Disease (TA-GVHD)
Iron Overload