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M2M Unit II > Finding Disease Genes > Flashcards

Flashcards in Finding Disease Genes Deck (10):
1

What looks for causal genes directly based on your own hypothesis (hypothesis driven), and is almost always wrong?

candidate gene association studies

2

What are genome-wide association studies?

testing hundreds of thousands/millions of markers (SNPs) across entire genome for correlations in diseased patients

4

What is are candidate gene association studies?

look for causal genes directly based on your own hypothesis (hypothesis driven)- almost always wrong

4

_______ are good for the discovery of genes involved in susceptibility to common complex diseases such as diabetes, asthma, and CAD.

Genome-wide association studies

5

What is a genetic linkage analysis?

search genome for segments disproportionately co-inherited along with disease- non-hypothesis driven

6

Genome-wide association studies are good for the discovery of genes involved in susceptibility to common ______ diseases such as _____.

complex; diabetes, asthma, CAD

7

Genetic linkage analysis is good for ________ but not good for ______.

Mendelian disorders; complex traits

8

What studies a gene directly based on your own hypothesis (hypothesis driven)?

candidate gene DNA sequencing

9

What searches the genome for segments disproportionately co-inherited along with disease (non-hypothesis driven)?

a genetic linkage analysis

10

What is candidate gene DNA sequencing?

study the gene directly based on your own hypothesis (hypothesis driven)