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Flashcards in firecracker feb 12 Deck (295):
1

erythema multiforme infectious causes

HSV
Mycoplasma pneumoniae

2

what is erythema multiforme

acute cutaneous hypersensitivity condition
immune mediated
target like lesions

3

erythema multiforme most common among

males
20-40

4

erythema multiforme other findings besides target lesions

malaise, mylagias
macules
plaques, vesicles

5

erythema multiforme lesions

red center
pale inner ring
red outer ring

6

meds linked to erythema multiforme

penicillins

7

erythema multiforme diagnosis

skin biopsy
increased lymphocytes
necrotic keratinocytes

8

erythema multiforme treatment

stop offending agent
corticosteroid
analgesics

9

how does membranous nephropathy present

edema
dyspnea

10

risk factors for autoimmune hepatitis

caucasian/northern europe
female
acute hep a and b infections
DR3,4

11

membranous nephropathy treatment

corticosteroids, cytotoxic agents, statins, ACEI

12

lab findings in membranous nephropathy

hyperlipidemia
hypoalbuminemia
proteinuria

13

What is the role of anticoagulation in the management of membranous nephropathy?

increase in coagulopathies
severe proteinura >5g/day

14

autoimmune hepatitis serological

Anti smooth muscle
anti live rkidney microsomal

15

autoimmune hepatitis treatment

prednisone
azathioprine

16

membranous nephropathy - immunoflourescnce

granular deposits of IgG and C3

17

What is found on electron microscopy in patients with membranous nephropathy?

sub-epithelial immune complex deposits

18

secondary membranous nephropathy

hep b, c
autoimmune - lupus
drugs - gold, penicillaine
malignancies

19

autoimmune hepatitis

circulating antibodies
hepatocellular inflamm
fibrosis

20

follicular carcinoma %

15%

21

what is the first and second step in working up someone with a thyroid nodule?

-ultrasound (FNA)
- radionucleotide scan if suspicious
- biopsy

22

What percentage of thyroid CA’s are from a medullary carcinoma?

5%

23

medullary carcinoma - cells

parafollicular/C cells
produce calcitonin

24

How does follicular thyroid CA commonly spread?

hematogenous spread --> present with mets

25

thyroid CA treatment

surgical removal
radioactive iodine ablation
lobectomy if less than 1cm
total thyroidectomy if greater than 1 cm

26

What medication is started post-operatively for patients who have undergone surgery for thyroid cancer?

levothyroxine

27

What is the most common sub-type of thyroid CA?

papillary

28

What is a common history in patients who develop papillary thyroid CA? How does it spread?

exposure to ionizing radiation
spreads thru lymphatics

29

prolactinoma signs & symptoms

F: galactorrhea, amenorrhea
M: loss of libido, erectile dysfxn, gyecomastia

30

prolactinoma =

hyperfunctioning adenoma of anterior pituitary

31

hormones secreted from anterior pituitary

My FLAT PiG
MSH, FSH, LH, ACTH, TSH, Prolactin, GH

32

prolactinoma treatment

bromocriptine or cabergoline ---> dopamine agonists
dopamine inhibits prolactin release

33

other causes of hyperprolactinemia

pregnancy
drugs
hypothyroid/hypothalamic damage

34

causes of central DI

idiopathic
trauma
tumors
anorexia

35

diabetes insipidus

can't retain water
water normally retained by reabsorbing it from urine

36

DI symptoms

polyuria, polydipsia, new onset nocturia

37

First Step Of workup for DI

urinarlysis
dilute urine, urine osm less than serum osm (290)
urine specific grav less than 1.06

38

causes of nephrogenic DI

hereidtary renal diseases
lithitum toxicity
hypokalemia
hypercalcemia

39

second step of DI workup

water deprivation test
no change in urine osm after water deprivation

40

DDAVP test

increased urine osm in central
no change in nephrogenic (renal resistance to ADH)

41

central DI treatment

desmopressin

42

nephrogenic DI treatment

underlying disorder
symptoms with hctz, indomethacin, amiloride

43

secondary adrenal insufficiency most commonly caused by

glucocorticoids

44

What infective infiltrative disorders may affect the adrenal glands?

TB
Histo
HIV

45

secondary adrenal insufficiency

failure of HPAxis
decreased ACTH

46

What pituitary neoplasms commonly suppress ACTH production?

pituitary adenoma

47

What are some causes of adrenal insufficiency?

- autoimmune destruction
-Tb, Hiv
- infarction of adrenal gland
- Waterhouse-Friderichsen
- DIC

48

what is low in adrenal insuffieiency

low morning cortisol, less than 5

49

What is a common cause of adrenal insufficiency in patients in a hypercoagulable state or in sepsis?

hemorrhagic adrenal infarction

50

What hormones are secreted by the adrenal cortex?

aldosterone
cortisol
androgen

51

What is “stress dosing” of steroids and when is it indicated in adrenal insufficiency?

increased doses given in cases of stress like infection or surgery

52

What may precipitate adrenal crisis?

stress - surgery, sepsis
look for hypotension, hyponatremia, hyperkalemia

53

What replacement therapy is needed in patients with primary adrenal failure in addition to prednisone?

aldosterone with fludrocortisone

54

What is the cosyntropin test and what would be considered an abnormal result?

differentiate 1 vs 2 ACTH def
ACTH analog
cortisol > 20 normal result
lower indicates non response, primary adrenal failure

55

What is a common life-threatening complication of adrenal insufficiency?

shock (adrenal crisis)

56

treatment for adrenal crisis

IV glucose and corticosteroids

57

What test is used to confirm acromegaly if IGF-1 are found to be elevated?

ORAL glucose tolerance test

58

What are two important metabolic complications of acromegaly?

DM
HLD

59

What can be used to treat persistent elevations in insulin growth factor 1 after transphenoidal resection of the growth hormone secreting pituitary adenoma?

radiation therapy

60

What constitutes an abnormal oral glucose tolerance test in patients with acromegaly?

GH remains greater than 2 within two hours after ingestion of 75g glucose

61

Patients who have been diagnosed with acromegaly based on elevated IGF-1 levels and positive glucose tolerance test require what further testing?

MRI of brain

62

What is the cause of obstructive sleep apnea in acromegaly?

GH causing macroglossia

63

acromegaly rx

somatostatin and dopamine analogues such as ocretotide and bromocriptine

64

CNS symptoms of acromegaly

bitemporal hemianopsia
headaches

65

body parts affected by acromegaly

hands, skull, jaw

66

cause of primary hyperPTH

single benign adenoma
hyperplasia of parathyroid glands

67

triad of primary hyper PTH

hypercalcemia
elevated PTH
elevated 24 hr urinary calcium

68

secondary hyperPTH

parathyroid glands chronically stimulated by hypocalcemia to release PTH

69

how does primary hyperPTH present

hypercalcemia
bones, stones, moans, groans, polyuria

70

causes of secondary hyperPTH

CKD
Malabsorption
Rickets
PseudohyperPTH

71

indications for surgical intervention in primary hyperPTH

elevated cr
hypercalcemia
kidney stones
osteoporosis

72

secondary hyperPTH labs

low calcium, high phosphorus
high PTH

73

cortisol production

hypothalamus produces CRH
pituitary produces ACTH
ZF of adrenal gland produces cortisol

74

what test to determine ACTH-independent vs ACTH-dependent cushing's

plasma ACTH

75

what causes glucose intolerance in Cushing's?

cortisol-stimulated gluconeogenesis
obesity-induced peripehral insulin resistance

76

How does a low-dose dexamethasone suppression test help diagnose Cushing’s syndrome?

normal morning cortisol following dexa should be s

77

Complications of cushing's

diabetes
CVD
opportunistic infections

78

imaging in cushings

look for source

79

infections in Cushing's syndrome

Nocardia
PCP
fungal

80

skin in Cushing's

thinning
bruising
striae
hyperpigmentation

81

acne in Cushings?

imablance in adnrogens, estogren, GnRH

82

osteoporosis in Cushings?

reduced calcium absorption in intestines and kidneys

83

lab abnormalities in Cushings

hypokalemia
hypercalciuria
metabolic alkalosis

84

Cushings work up

24 urinary free cortisol test (3x)
low dose dexamethasone suppresion test

85

Cardiogenic Shock

decrease CO
increase SVR
increase PCWP

86

Hypovolemic Shock

decrease CO
increase SVR
decrease PCWP

87

Neurogenic Shock

decrease CO
decrease SVR
decrease PCWP

88

Septic Shock

increase CO
decrease SVR
decrease PCWP

89

Pharmacologic Agents in Cardiogenic Shock

Dopamine - vasopressor
Dobutamine - inotrope

90

Shock =

circulatory collapse
inadequate blood delivery resulting in hypoperfusion of tissues

91

How is anaphylactic shock managed?

airway maintenace
epinephrine
diphenhydramine
IV fluids

92

cardiogenic shock defined as

hypotension below 80-90 or 30mmhg below baseline
urine output less than 20 ml/hr

93

causes of cardiogenic shock

acute mi
arrhythmias
tension PTX
cardiac tamponade
massive PE

94

neurogenic shock =

SNS failure causing widespread peripheral vasodilation and bradycardia

95

anaphylactic shock =

type I hypersenisitivty rxn

96

etiology of neurogenic shock

CNS or spinal cord injury

97

cardiogenic shock =

heart fails to generate sufficient CO to perfuse tissues

98

causes of hypovolemic shock

hemorrhage
excess fluid loss

99

cause of anaphylactic shock

massive degranulation of mast cells and basophils in response to allergic rxn

100

management of neurogenic shock

IV fluids, vasoconstrictors to treat vasodilation
atropine for braycardia

101

management of hypovolemic shock

IV fluids or transfusions
surgery
dressing if due to burns

102

hemodynamic effects of cardiogenic shock

decrease in SV
increase in EDP and ESV

103

cardiogenic shock - PE findings

JVD, pulm edma
AMS
cool, clammy skin
weak thready pulse

104

management of shock related to MI

revascularization
use of aspirin and heparin

105

clinical features of neurogenic shock

warm, well perfused skin
low-normal urine output

106

symptoms of ARDS - focus on breath sounds

wheezing
rales
rhonchi

107

ARDS

acute lung inury
complement activation --> lung damage
refractory hypoxemia

108

PaO2/FiO2 ratio for ARDS

<200

109

ARDS lab findings

resp alkalosis
decrease o2
decrease co2

110

causes of ARDS, A

aspiration
acute pancreatitis
air or amniotic embolism

111

causes of ARDS, R

radiation

112

causes of ARDS, D

drug over dose
DIC
drowning

113

causes of ARDS, s

shock
sepsis
smoke inhalation

114

CXR for ARDS

bilateral pulmonary edema with infiltrates

115

BCC risk factors

p53, HPV

116

BCC

most common
sun exposed areas

117

BCC lesion

pearly, waxy apperance
telangiectases throughout lesion

118

BCC diagnosis

skin biopsy

119

BCC treatment

electrodessication and curettage
surgical excision
cryotherapy
topical meds
radiation therapy

120

BCC - meds

5FU
imiquimod
tazarotene

121

BCC -radiation

extensive dz
can't undergo surgery

122

SCC risk factors

HPV
actinic keratosis

123

SCC lesion

scaly, ulercated skin lesion
shallow ulceration with healed up borders

124

gold standard for diagnosing melanoma

excisional skin biopsy with a 1-2mmof normal appearing skin

125

melanoma complications

scarring, keloid formation, metastasis, death

126

cause of dehydration in HHNK

increased blood glucose --> increased insulin demand --> increased plasma osm --> osmotic diuresis --> dehydration

127

HHNK lab values

elevated glucose, 600+
elevated plasma osmolality, +350
no ketones

128

potassium levels in HHNK

normal despite low total-body stores

129

what prevents ketoacidosis in HHNK

some circulating insulin which prevents lipolysis

130

HHNK ABG

normal ph, normal bicarb

131

HHNK presentation

polydipsia, polyuria, AMS, dehydration

132

Cr in HHNK

prerenal azotemia

133

HHNK treatment

NS
Insulin
glucose
potassium

134

when glucose reaches 250-300 in HHNK

given 5% dextrose

135

Hemophilia A

Factor 8 def

136

Hemopihilia A&B inheritance patterns

x linked recessive

137

hemophilia lab values

prolonged PTT

138

hemophilia symtpoms

hemarthroses (bleeding into joints)
intramuscular hematomas

139

Hemophilia B

def of Factors 9

140

Hemophilia A treatment

Factor 8 during acute bleeding episodes
minor dz, DDAVP

141

Hemophilia B treatment

factor 9 concentrates
not DDAVP

142

coccidiomycosis treatment

self resolving

143

coccidiomycosis skin findings

genearlized macular erthematus eruption of eryhthema nodosum

144

coccidiomycosis symptoms

fevers/chills/night sweats
chest pain

145

coccidiomycosis symptom constellation

erythema nodusum, fever, chest pain, arthrlagias

146

extrapulmonary sites of TB

meningitis
potts - bones of spine

147

Tb treatment

RIPE for 2 months
4 months of isoniazid & rifampin

148

asymptomatic TB treatment

isoniazid for 9 months

149

Tb test - 5mm induration

HIV positive
close contact
CXR changes
immunosuppression

150

gastritis triggers (3)

alcohol
nsaid
h pylori

151

gastritis - best diagnostic study

upper endoscopy with mucosal biopsy

152

gastritis - determining extent of erosions

double contrast barium study

153

gastritis - lab tests

CBC
stool guiac
stool antigen and urea breath test

154

CKD most common causes

HTN
DMT2
Glomerulonephritis

155

stage III CKD

30-59

156

5 absolute indications for emergent dialysis in CKD

acidosis
electrolyte abnormalities
ingestion of toxins
overload of fluid
uremia

157

stage V CKD

less than 15

158

CKD sodium and water retention

HTN, accelerated atherosclerosis
peripheral edema
CHF

159

Renal Osteodystrophy in CKD

hyperphosphatemia stimulates PTH
decreased alpha1vit D causes increased PTH
low calcium
osteitis fibrosis cystica

160

treatment of CKD anemia

EPO stimulating agents (can increase BP & thrombotic risk)

161

Stage IV CKD

15-29

162

CKD anemia

decreased EPO
normochromic, normocytic anemia

163

CKD labs

elevated Bun, CR
increase K, phosphate
decreased Na, Ca
anemia
metabolic acidosis

164

volume managemnt in CKD

loop diuretics

165

CKD anion-gapped metabolic acidosis

decreased excretion of H ions in ammonium
decreased renal excretion of organic anions

166

hyperkalemia in CKD

inability to excrete potassium

167

platelet dysfunction in CKD

uremia-induced
increased bleeding risk

168

CKD increased infection risk

uremia-induced neutrophil dysfunction

169

CKD metabolic acidosis treatment

sodium bicarb

170

CKD stage 1

90+

171

CKD dietary modifications

low phosphate diet, phosphate binders
vit d analogues
low potassium diet
protein restriction

172

CKD stage II

60-89

173

treatment of AIN

-supportive
-corticosteroids

174

AIN presentation

ARF w/
fever, rash, N/V, malaise

175

AIN lab values

increase in Cr
eosinophilia

176

AIN caused by what toxins?

cadmium
lead
copper
mercury
mushrooms

177

AIN caused by what drugs?

Pencillin, NSAID, Allopurinol, Diuretics, Cephalosporins, PPI, Sulfonamide/Sulfasalazine, Rifampin

178

AIN caused by systemic diseases?

Strept, Legionella
Sarcoidosis, Amyloidosis,
SLE
Myoglobinuria, high uric acid levels

179

AIN urinalysis

granual and epithelial casts

180

AIN kidney biopsy

inflamm cells in interstitium
tubular cell necrosis

181

AIN complications

ATN
ARF, CRF
RPN

182

septic arthritis PE findings

warm, red, tender joint
skin lesions

183

septic arthritis cause in young male

N. gonorrhea

184

septic arthritis- most common pathogen

s. aureus

185

septic arthritis in immunocompromised

fungal, candida

186

treatment for S. aureus septic arthritis

nafcillin/oxacillin/dicloxacillin

187

treatment for N. gonorrhoeae septic arthritis

ceftriaxone + axithro/doxy
surrigical irrigation and drainage usually not necessary

188

septic arthritis in sickle cell pts and IV drug users

Salmonella
Pseudomonas

189

gram negative septic arthritis treatment

aminoglycoside

190

MRI in septic arthritis

confirm joint effusion

191

joint aspirate in septic arthritis

wbc 50000+
high neutrophil count
low glucose

192

septic arthritis treatment

surgical irrigation and drainage

193

septic arthritis - what to monitor for treatment efficacy

CRP

194

septic arthritis lab findings

WBC 10K+
ESR 30+
CRP 5+

195

septic arthritis symptoms

pain in joint
fever
pain with passive ROM

196

Malaria affects which RBCs

vivax/ovale: reticulocytes
malariae: mature RBC
falciparum: reticulocytes & RBC

197

malaria vector

Anopheles mosquito

198

malaria symptoms

chills, myalgia, HA
NVD
splenomegaly

199

hypnozoites associated with

vivax/ovale

200

fever & malaria

falciparum constant
ovale and vivax - q48hr
marlariae - q72h

201

most severe form of malaria with cerebral, renal & pulm symptoms

falciparum

202

primaquine as treatment and prophylaxis for malaria in

Mexico and Argentina

203

treatment of malaria in chloroquine resistant areas

quinine sulfate + tetracycline
atovaquone-proguanil
artemether-lumefantrine

204

med for Pvivax and Povale malaria

primaquine phosphate, two weeks

205

malaria prophylaxis

chloroquine
mefloquine

206

malaria diagnosed with

perpheral blood smear with giemsa-staining

207

primary syphilis

painless chancre (ulcerated penile lesion)

208

4 causes of false positives with VDRL

viruses (mono, hepatitis)
drugs
rheumatic fever
lupus and leprosy

209

tertiary syphilis

gumma formation
aortitis
neurosyphilis

210

congenital syphilis initial symptoms

rhinitis
lesions on palms/soles
HSM, jaundice
hemolytic anemia, thrombocytopenia

211

neurologic symptoms of tertiary syphilis

tabes dorsalis
argyll-roberston pupils
broad based ataxia
stroke

212

condyloma lata

smooth, flat, lessions in most areas

213

screening test and confirmatory test for syphilis

VDRL or RPR
FTA-ABS

214

negative VDRL with positive FTA

sucessfully treated syphilis

215

treatment for primary syphilis

benzanthine penicillin IM
doxy or tetracycline for 2 weeks

216

treatment of secondary and tertiary syphilis

benzathine pencilline g IM for 3 wks
doxy for 28 d

217

three general causes of acquired long QT syndrome

drugs
electrolyte imbalance
MI

218

long qt =

delayed in repolarization of myocardium

219

What effect does every drug that causes prolongation of the QT interval have?

block cardiac Ikr current mediated postassium channels

220

diagnosis of Qt prolong on ECG?

qt/sqrt(RR)
less than 440

221

electrolyte imbalances that can cause long qt

hypokalemia
hypomagnesium
hypocalcemia

222

drugs that cause long qt

quinidine, amiodarone
haloperiodal, methadone
cisapride
erythromycen
aresenic trioxide

223

prolonged QT life threatening complication

torsades de pointes

224

long qt treatments

stop drug, correct electrolytes, IV mag sulfate

225

lactase absorbed ...

brush border of enterocytes

226

borborygmi

rumbling noises made by gas and fluid in intestines

227

tests for lactose intolerance

lactose absorption test (minimal increase in serum glucose)
lactose breath hydrogen test

228

lactose intolerance stool

bulky, frothy, watery

229

lactase deficiecny pathophysiology

lactase production decreases over time
injury to small intestine

230

etiologies of DIC

1) sepsis
2) trauma
3) malignancy
4) ob complications
5) severe intravascular hemolysis (malaria, AHTR)

231

pathogenesis of DIC

1) exposure of excess tissue factor
2) coagulation
3) thrombosis & fibrinolysis
4) hemorrhage

232

chronic DIC clinical manifestations

asymptomatic
predilection for thrombosis

233

factors that determine whether DIC will be acute or chronic

- etiology
- rate

234

DIC lab findings

1) thrombocytopenia
2) shistocytes
3) decreased fibrinogen, elevated PTT, PT
4) elevated
FDP, D-dimer

235

lab findings in chronic DIC

elevated FDPs, D-dimer, schistocytes
no coagulopathies

236

DIC supporative care

transfuse platelets if less than 50K
increased INR/decrease in fibrinogen: FFP or cryoprecipate

237

purpura fulminans

rate but fatal complication of DIC
extensive tissue thrombosis and skin necrosis
treat with proctein c

238

what predisposes to myxedema coma?

longstanding uncontrolled hypothyroidism (usually primary)

239

supportive measures in myxedema coma?

intubation with mechanical ventilation
passive rewarming
non-dilute fluids with electrolytes and glucose

240

myxedema coma =

severe hypothyroidism
with
decreased MS, hypothermia, hyponatremia

241

What makes airway management challenging in a patient with myxedema coma?

nonpitting edema - enlarged tongue, edematous pharynx

242

4 complications of myxedema coma

cardiac abnormalities
lipid abnormalities
anemia
depression

243

myxedema coma labs

TSH, free T4, cortisol

244

myexedma coma clinical presentation

decreased MS
hypothermia
hyponatremia
hypercapnia

245

myxedema cardiac abnormalities

low cardiac output, hypotension, CHF
reverse with correction of thyroid hormones

246

drug given during myxedema coma

IV levothyroxine (T4)

247

hereditary elliptocytosis genetic mutations

eryhtrocye membrane proteins: alpha spectrin, beta spectrin

248

hereditary elliptocytosis more prevalent in africa...

protection against malaria

249

primary cause of symptoms in hereditary elliptocytosis

hemolytic anemia/chronic hemolysis

250

treatment of hereditary elliptocytosis with severe symptoms

splenectomy
blood transfusion

251

most severe type of hereditary elliptocytosis

hereditary pyropoikilocytosis

252

best initial treatment for hereditary elliptocytosis

no treatment
folic acid

253

6 states that worsen hemolytic anemia in hereditary elliptocytosis?

neonates (high 2,3BPG)
renal allograft rejection
TTP/HUS
infection
pregnancy
b12 def

254

roles of vWF in hemostasis

adheres to platelets and subendothelial components
binds favtor VIII

255

vWD diagnostic tests

plasma vwf antigen
plasma vwf activity (ristocetin cofactor assay)
factor VIII activity

256

wVD clincial scenarios

difficult to control epistaxis
excessive bleeding following invasive procedures
menorrhagia
excessive peripartum bleeding

257

vWD pts before surgery should be given

vWF concentrate

258

presenting symptoms of FSGS

edema
foamy urine
HTN
dyspnea

259

FSGS risk factors

IV drug use
HIV

260

FSGS biopsy

sclerotic changes in glomeruli

261

FSGS treatment

steroids, cytotoxic agents, ACEI, statins

262

FSGS lab findings

HLD, hematuria, high levels of proteinuria, hypoalbuminemia

263

wegner's biopsy

granulomatous inflamm of blood vessels

264

MPGN etiologies

Hep B,C
Lupus
bacterial endocarditis
autoimmune, idiopathic

265

MPGN lab findings

hematuria
hypocomplementemia

266

osmotic diuresis leading to hypernatremia

mannitol
glucosuria

267

renal cell CA triad

hematuria
palpable flank masses
flank pain

268

renal cell CA paraneoplastic syndromes

PTHrp, EPO, ACTH, Renin

269

causes of hypervolemic hypernatremia

cushings
exogenous steroids
primary hyperaldosteronism

270

hypercalcemia ekg findings

av block, shortened qt

271

renal sodium loss -- hypovolemic hypernatremia

diuretics
osmotic diuresis
renal failure

272

extra renal sodium loss -- hypovolemic hypernatremia

diarrhea, diaphoresis, respiratory

273

good pastures triad

anti GBM antibodies
rapidly progressive GN
pulmonary hemorrhage

274

MPGN treatment

steroids with aspirin or dipyridamole

275

polyarteritis nodosa risk factors

hep B, C, older age, male

276

polyarteritis nodosa - alternative to tissue biopsy

mesenteric or renal arteriography emonstrating multiple aneurysms and irregular constrictions

277

polyarteritis nodosa =

vasculitis of medium sized muscular arteries
segmental transmural inflamm leads to fibrinoid necrosis

278

polyarteritisi nodosa, rule out

ANCA

279

polyarteritis nodosa presentation

systemic symptoms
multisystem organ damage

280

polyarteritis nodosa - organ most commonly involved

kidney

281

PAN transmural inflamm leads to

aneurysm of arterial wall

282

PAN labs

increase WBC, ESR
decreased hgb, hct
proteinuria, hematuria

283

polyarteritis nodosa - body parts affected

kidneys, heart, gi tract
muscle, nerves, joints

284

PAN treatment

steroids
cyclophosphamide

285

PAN skin manifestations

erythema nodosum like
palpable purpura similar to HSP

286

PAN gi symptoms

ischemic abd pain (after meals, leads to wt loss)

287

PAN CNS symptoms

named nerve s- both motor and sensory deficits

288

PAN diagnosis

biopsy of tissue

289

HSP pathophysiology

small vessel vascuilitis characterized by IgA

290

HSP joint manifestations

transient non-migratory arthralgia

291

HSP renal

iga immune complex deposition

292

HSP treatment

mainly self limiting/supportive
otherwise, prednisone and acei and diuretics

293

HSP GI symptoms

colicky abd pain
increased risk of intussusception

294

HSP urinalysis

blood and protein in ruine
rBC casts

295

HSP tetrad

palpable purpura
polyarticular arthritis
abd pain
renal failure