FIrst Aid: Psychopharmacology Flashcards Preview

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Flashcards in FIrst Aid: Psychopharmacology Deck (163)
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1

What antidepressant class is used to treat enuresis?

TCAs

2

What antidepressant class is used to treat Autism?

SSRIs

3

What antidepressant class is used to treat premenstrual dysphoric d/o?

SSRIs

4

What is the treatment for the depressive phase of manic depression?

SSRIs, bupropion

5

What is the treatment for insomnia?

-Mirtazapine
-TCAs

6

What antidepressant class is used to treat neuropathic pain?

TCAs

7

What antidepressant class is used to treat dysthymia?

SSRIs

8

What is the MOA of TCAs?

-Inhibit reuptake of NE and 5-HT

9

Why are TCAs not first-line agents?

higher incidence of side effects, require greater monitoring of dosing and are lethal in overdose

10

What is the hallmark of TCA toxicity?

widened QRS (>100 msec)

11

List examples of TCAs

-ipramine
-triptyline
Doxepin

12

Which TCA is least likely to cause orthostatic hypotension?

nortriptyline

13

Which TCA is least sedating (least anticholinergic side effects)?

desipramine

14

Which TCA is the most serotonin specific?

Clomipramine

15

What is clomipramine specifically used to treat?

OCD

16

How do you treat a TCA overdose?

IV sodium bicarbonate

17

What are the major TCA side effects?

-antiHistamine (sedation)
-antiAdrenergic (orthostatic hypotnesion, tachycardia, arrhythmia)
-antiMuscarinic (dry mouth, constipation, urinary retention, blurred vision, tachycardia)
-weight gain
-lethal in overdose
-3 C's

18

What dosage of TCA's is lethal in OD?

1 week supply

19

What are the 3 C's of TCAs?

-Convulsions
-Coma
-Cardiotoxicity

20

What is the MOA of MAOIs?

prevent the inactivation of biogenic amines such as NE, 5-HT, dopamine, and tyraminMOA-e (increase amount of these transmitters available in synapses)

21

MAO-A preferentially deactivates what neurotransmitter?

serotonin

22

MOA-B preferentially deactivates what neurotransmitter?

NE/epinephrine

23

MOAIs are very effective for what conditions?

-Refractory depression
-Refractory panic disorder

24

List some examples of MAOIs.

-Phenelzine
-Tranylcypromine
-Isocarboxazid

25

What are the common side effects of MAOIs?

-Orthostatic hypotension
-Drowsiness
-Weight gain
-Sexual dysfunction
-Dry mouth
-Sleep dysfunction

26

What happens when SSRIs and MAOIs are taken together?

serotonin syndrome (lethargy, restlessness, confusion, flushing, diaphoresis, tremor and myoclonic jerks)

27

What does serotonin syndrome progress into?

Hyperthermia
Hypertonicity
Rhabdomyolysis
Renal Failure
Convulsions
Coma
Death

28

What is the first step when suspecting serotonin syndrome?

discontinue medication

29

How long must you wait before you switch from an SSRI to MAOIs?

at least 2 weeks

30

When would you get a hypertensive crisis when on MAOIs?

if you take it with tyramine-rich food or sympathomimetics