Flashcards in FIrst Aid: Psychopharmacology Deck (163)
What antidepressant class is used to treat enuresis?
What antidepressant class is used to treat Autism?
What antidepressant class is used to treat premenstrual dysphoric d/o?
What is the treatment for the depressive phase of manic depression?
What is the treatment for insomnia?
What antidepressant class is used to treat neuropathic pain?
What antidepressant class is used to treat dysthymia?
What is the MOA of TCAs?
-Inhibit reuptake of NE and 5-HT
Why are TCAs not first-line agents?
higher incidence of side effects, require greater monitoring of dosing and are lethal in overdose
What is the hallmark of TCA toxicity?
widened QRS (>100 msec)
List examples of TCAs
Which TCA is least likely to cause orthostatic hypotension?
Which TCA is least sedating (least anticholinergic side effects)?
Which TCA is the most serotonin specific?
What is clomipramine specifically used to treat?
How do you treat a TCA overdose?
IV sodium bicarbonate
What are the major TCA side effects?
-antiAdrenergic (orthostatic hypotnesion, tachycardia, arrhythmia)
-antiMuscarinic (dry mouth, constipation, urinary retention, blurred vision, tachycardia)
-lethal in overdose
What dosage of TCA's is lethal in OD?
1 week supply
What are the 3 C's of TCAs?
What is the MOA of MAOIs?
prevent the inactivation of biogenic amines such as NE, 5-HT, dopamine, and tyraminMOA-e (increase amount of these transmitters available in synapses)
MAO-A preferentially deactivates what neurotransmitter?
MOA-B preferentially deactivates what neurotransmitter?
MOAIs are very effective for what conditions?
-Refractory panic disorder
List some examples of MAOIs.
What are the common side effects of MAOIs?
What happens when SSRIs and MAOIs are taken together?
serotonin syndrome (lethargy, restlessness, confusion, flushing, diaphoresis, tremor and myoclonic jerks)
What does serotonin syndrome progress into?
What is the first step when suspecting serotonin syndrome?
How long must you wait before you switch from an SSRI to MAOIs?
at least 2 weeks