Fluoro and Drugs for UTI Flashcards Preview

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Flashcards in Fluoro and Drugs for UTI Deck (30):
1

common pathogens of UTI infections

  • E-coli (70-80%)
  • Staphylococcus saprophytricus 

2

Catheter-associated UTIs are caused by what organisms

gram negative

 

3

List the Fluoroquinolones 

  1. Ciprofloxacin
  2. Norfloxacin
  3. Ofloxacin
  4. Levofloxacin
  5. Moxifloxacin
  6. Gatifloxacin
  7. Gemifloxacin 

4

What two Fluoroquinolones are active against anaerobes

  • Moxifloxacin
  • Gemifloxacin 

5

which Fluoroquinolones is used against community acquired PNA

Levofloxacin (Levaquin) 

6

MOA of Fluoroquinolones? Static or cidal?

inhibit DNA gyrase and Topoisomerase IV

*Bactericidal 

7

Spectrum of Fluoroquinolones 

  • aerobic G- 
  • good G+

8

which Fluoroquinolones has anti-pseudomonal coverage

cipro

9

DOC anthrax 

cipro 

10

route of administration of Fluoroquinolones 

well absorbed orally 

11

which Fluoroquinolones can be used to treat prostatitis 

Norfloxacin

Ofloxacin

12

Adverse effects of Fluoroquinolones 

  • Gi disturbances
  • Increase QT interval
  • Cartilage erosion
  • Tendon rupture 

13

Fluoroquinolones are contraindicated in what patient populations

  • Pregnant or nursing women
  • children under 18 years old (cartilage damage) 

14

MOA of Metronidazole? static or cidal

fragment DNA

Bacteriocidal

15

coverage of Metronidazole 

  • Anaerobes 
    • G- and G+ 

16

DOC pseudomembranous colitis (C. Diff) 

Metronidazole 

17

route of administration of Metronidazole 

  • oral
  • IV
  • topical

18

adverse reactions of Metronidazole 

metallic taste 

19

what is a common property of Nitrofurantoin and Methenamine

  • exclusive UTI drugs
  • high urinary concentrations 

20

MOA of Nitrofurantoin (Furadantin)? static or cidal?

  • damages bacterial DNA
  • static and cidal 

21

spectrum of coverage of Nitrofurantoin

  • used for UTI
  • active against a wide spectrum of G+ and G-

22

route of administration of Nitrofurantoin

oral

23

contraindications of Nitrofurantoin

  • creatinine clearance < 50 mL/min
  • pregnancy (38-42 weeks)
  • < 1 month old

24

toxicity of Nitrofurantoin 

  • hepatocellular damage
  • hemolytic anemia
  • interstitial pulmonary fibrosis

25

route of administration of Methenamine

oral

26

MOA of Methenamine

  • decomposes to formaldehyde and ammonia in acidic urinary tract

*acidic urine increases theraputic action 

27

spectrum of Methenamine 

  • G- organisms
    • nearly all bacteria are sensitive
    • but bacteria that increase pH of urine inhibit release of formaldehyde 

*especially E-coli 

28

resistance mechanisms to Methenamine

bacterial resistance to formaldehyde does not develop

29

toxicity of Methenamine

essentially non-toxic 

30

contraindications to administer Methenamine

  • hepatic insufficiency
  • renal insufficiency