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Flashcards in sulfonamides and miscellaneous Deck (31):
1

What is the brand name of sulfamethoxazole + Trimethoprim 

co-trimaxazole, TMP-SMX (Bactrim) 

2

What is the route of administration of sulfamethoxazole + Trimethroprim (Bactrim) 

  • oral
  • IV only in extreme situations 

3

List the sulfonamides 

  • sulfamethoxazole + trimethoprim (Bactrim)
  • sulfamethoxazole (Gantanol)
  • Sulfasalazine
  • silver sulfadiazine  

4

route of administration of sulfamethoxazole (Gantanol)

oral

5

route of administration of Sulfasalazine 

oral

6

route of administration of silver sulfadiazine 

topical

7

sulfamethoxazole (Gantanol) has a high concentration where

high urine concentration 

8

what is a major different between the sulfonamides

rate of absorption, excretion and solubility in the urine 

9

MOA of sulfamethoxazole. static or cidal? 

competes with PABA in the synthesis of bacterial folic acid

  • generally bacteriostatic
  • bactericidal in the urinary tract 

10

MOA of trimethoprim

prevents the reduction of dihydrofolate to tetrahydrofolate 

11

spectrum of coverage of Sulfamethoxazole 

inhibit G+ and G- organisms 

12

DOC UTI infections (first attack) 

Co-trimoxazole (Bactrim) 

13

contraindications of Bactrim

  • avoid use near term or in nursing premature or jaundiced infants
    • sulfa can cross placenta and blood brain barrier

14

How much higher is Bactrim's concentration in the urine than in the plasma 

urine concentration is 10-20 times higher 

15

Toxicities of sulfa drugs

  • drug sensitivity (allergy 6%)
  • Steven-Johnson Syndrome
  • Kernicterus (sulfa compete with binding of bilirubin to plasma proteins) 

16

contraindications of sulfa drugs

should not be given to infants < 2 months old 

17

What is the one Lipopeptide Abx 

Daptomycin (Cubicin)

18

MOA of Daptomycin (Cubicin)? static or cidal?

binds to bacterial membrane and causes a rapid depolarization of membrane potential

  • bactericidal 

19

spectrum of coverage of Daptomycin (Cubicin) 

G+ aerobic and anaerobic 

20

route of administration of Daptomycin (Cubicin) 

IV 

21

what abx can be used as an alternate to vancomycin to treat serious G+ infections 

Daptomycin (Cubicin) 

22

MOA of Mupirocin (Bactroban) 

bacterial protein and RNA synthesis are inhibited

23

spectrum of coverage of Mupirocin (Bactroban)? Static or cidal?

good against G+ and some G-

  • bacteriostatic at low concentrations
  • bactericidal at high concentrations

24

route of administration of Mupirocin (Bactroban)

topical; intranasal

25

what abx is used to treat impetigo caused by S.aureus and/or streptococcus pyogenes 

Mupirocin (Bactroban)

26

Name the two polypeptide Abx

  • Polymyxin B
  • Colistin 

27

MOA of polypeptide Abx

G- infections 

28

MOA of polymyxin B 

binds to G- bacterial cell membrane phospholipids (lipid A of endotoxin

29

spectrum of coverage of polypeptide abx 

  • G- infections
  • No effect in G+

30

toxicity of polypeptide abx

nephrotoxicity 

31

route of administration of polypeptide abx

topical