Formative Flashcards

1
Q

Antabuse - a drug used to treat alcoholism work by inhibiting

Select one:

a. alcohol phosphatase
b. alkaline phosphatase
c. aldehyde dehydrogenase
d. aldehyde phosphatase
e. alcohol dehydrogenase

A

Aldehyde dehydrogenase

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2
Q

Acute pancreatitis is associated with

Select one:

a. opiate use
b. diuretics
c. 2nd generation cefalosporins
d. 3rd generation cefalosporins
e. steroid use

A

Steroid use

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3
Q

Alcohol is associated with

Select one:

a. an accumulation of lipid in hepatocytes Correct
b. an increased number of plasma cells in portal areas
c. granulomas surrounding bile ducts
d. vascular congestion in portal tracts
e. an accumulation of iron in hepatocytes

A

An accumulation of lipid in hepatocytes

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4
Q

The legal age of drinking alcohol whilst at supervised at home is

Select one:

a. 5
b. 16
c. 18
d. 10
e. 15

A

5

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5
Q

The liver is divided into

Select one:

a. 3 segments
b. 8 segments
c. 9 segments
d. 5 segments
e. 2 segments

A

8

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6
Q

The recommended number of units of alcohol for a man in one week is

Select one:

a. 18 units
b. 16 units
c. 20 units
d. 14 units
e. 21 units

A

14

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7
Q

The respiratory center of the brain lies within the

Select one:

a. brainstem
b. cerebellum
c. frontal cortex
d. thalamus
e. occipital cortex

A

Brainstem

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8
Q

Persistent vomiting causing a gastric tear is known as a

Select one:

a. Watermelon stomach
b. Hypertensive portal gastropathy
c. GAVE - gastric antral vascular ectasia
d. Mallory Weiss tear Correct
e. Boerrhave syndrome

A

Mallory weiss tear

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9
Q

Portal hypertension is most associated with

Select one:

a. hepatomegaly
b. positive Murphy’s sign
c. positive Courvoisier’s sign
d. splenomegaly
e. Cullen’s sign

A

Splenomegaly

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10
Q

A patient with LFTs showing a normal GGT, AST and ALT with high Alk Phos is most likely to have

Select one:

a. pulmonary disease
b. viral hepatitis
c. recently drunk significant amounts of alcohol (binge drinking)
d. chronic alcoholism
e. bone disease

A

Bone disease

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11
Q

In general, females become intoxicated more rapidly than males because

Select one:

a. they tend to have a higher BMI
b. they are less accustomed to drinking
c. they consume different types of alcohol
d. they tend to have less alcohol dehydrogenase
e. they tend to have smaller livers

A

Tend to have less alcohol dehydrogenase

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12
Q

Which nerve supplies the heart?

Select one:

a. phrenic
b. accessory
c. cephalic
d. vagus
e. azygous

A

Vagus

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13
Q

Which of these microscopic features is NOT present within a portal tract?

Select one:

a. hepatocyte
b. bile duct
c. vein
d. artery
e. lymphocyte

A

Hepatocyte

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14
Q

Persistent vomiting may result in

Select one:

a. metabolic alkalosis
b. metabolic acidosis
c. respiratory acidosis
d. net normal pH
e. respiratory alkalosis

A

Metabolic alkalosis

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15
Q

A patient with haematemesis may suffer from

Select one:

a. neurogenic shock
b. cardiogenic shock
c. septic shock
d. hypovolaemic shock
e. anaphylactic shock

A

Hypovolaemic shock

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16
Q

The recommended number of units of alcohol for a woman in one week is

Select one:

a. 18 units
b. 14 units
c. 16 units
d. 21 units
e. 20 units

A

14

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17
Q

In a restaurant today a standard glass of wine (175mls) is likely to contain approximately

Select one:

a. 3 units of alcohol
b. 1 unit of alcohol
c. 1.5 units of alcohol
d. 2 units of alcohol
e. 0.5 units of alcohol

18
Q

After use of muscle glycogen the liver can produce “new glucose” through

Select one:

a. gluconeogenesis
b. glycophosphorylation
c. glycogenolysis
d. glucogenolysis
e. glyconeogenesis

A

Gluconeogenesis

19
Q

Which of these speeds up the elimination of alcohol form the body

Select one:

a. all of the above
b. water consumption
c. caffeine consumption
d. glucose solution
e. none of the above

A

None of the above

20
Q

Which of the following clinical signs can be associated with alcohol?

Select one:

a. Caput medusa
b. Kayser Fleischer ring
c. Roth spots
d. Janeway lesions
e. corneal arcus

A

Caput medusa

21
Q

Alcohol is initially metabolised by

Select one:

a. fumarate hydratase
b. cytochrome p450
c. alcohol hydratase
d. alcohol dehydrogenase
e. alcohol phosphatase

A

Alcohol dehydrogenase

22
Q

Jaundice as a result of alcoholic hepatitis is caused by an accumulation of

Select one:

a. conjugated biliverdin
b. unconjugated bilirubin
c. conjugated bilirubin
d. haptoglobin
e. unconjugated biliverdin

A

Conjugated bilirubin

23
Q

Chronic alcoholism is associated with

Select one:

a. reactive pericarditis
b. restrictive cardiomyopathy
c. hypertrophic cardiomyopathy
d. dilated cardiomyopathy
e. arrhythmogenic right ventricular dysplasia

A

Dilated cardiomyopathy

24
Q

Alcohol confers the strongest risk for

Select one:

a. oesophageal squamous cell carcinoma
b. hepatocellular carcinoma
c. pulmonary squamous cell carcinoma
d. colorectal adenocarcinoma
e. pulmonary adenocarcinoma

A

Hepatocellular carcinoma

25
The ligamentum teres within the falciform ligament is formed from which embryological structure? Select one: a. mesonephric duct b. umbilical vein c. umbilical artery d. urachus e. vitelline duct
Umbillical vein
26
The term "inotrope" refers to Select one: a. cardiac rate b. ventricular filling volume c. total peripheral resistance d. cardiac contractility e. atrial filling volume
Cardiac contractility
27
Severe hepatitis is associated with Select one: a. hepatoreticular syndrome b. hepatorenal syndrome c. hepatorespiratory syndrome d. hepatocardiac syndrome e. hepatobiliary syndrome
Hepatorenal
28
The liver enzyme ALT is short for Select one: a. Alanine aminotransferase b. Alcohol Transferase c. Amino L-transferase d. Alyl Transferase e. Aspartate l-transferase
Alanine aminotransferase
29
In the normal metabolic pathway the substance from which bilirubin is formed is Select one: a. haptoglobin b. porhyrin c. urobilinogen d. biliverdin e. haemaglobin
biliverdin
30
Alkaline phosphatase is NOT concentrated in the Select one: a. placenta b. kidney c. lung d. liver e. bone
Lung? (didn't see the answer but presumably?)
31
The liver enzyme AST is short for Select one: a. Aspartate transaminase b. Aspartate Transferase c. Alanine synthase d. Aspartate aminotransferase e. Alanine S-transferase
aspartate aminotransferase
32
Which clotting factor is NOT made in the liver? Select one: a. X b. VIII c. IX d. VII e. II
VIII
33
Fibrosis.cirrhosis of the liver is mediated by which type of cell? Select one: a. lymphocytes b. hepatocytes c. interstitial cells of Ito d. macrophages e. neutrophils
interstitial cells of Ito
34
Which of the following is NOT associated with acute pancreatitis? Select one: a. Caput Medusae b. renal failure c. resp failure d. Grey Turner's sign e. Cullen's sign
? (either renal failure or caput medusae)
35
Treatments intended to manage ascites in cirrhosis aim to reduce Select one: a. phosphate levels b. calcium levels c. magnesium levels d. sodium levels e. potassium levels
Sodium
36
Microscopically, hepatocytes are bordered by Select one: a. Bowman's space b. the space of Disse c. venules d. Virchow-Robin space e. arterioles
Space of dise
37
Aspiration pneumonia typically occurs in the Select one: a. upper post segment of the left lower lobe b. lower segment of the right lower lobe c. lower segment of the left lower lobe d. proximal segment of the right median lobe e. superior segment of the right lower lobe
superior segment of the right lower lobe
38
Embryologically the liver is derived from the Select one: a. foregut b. hindgut c. the cloaca d. urachus e. vitelline duct
foregut
39
Alcohol is know to Select one: a. decrease blood LDL levels b. increase blood triglyceride levels c. increase blood LDL levels d. increase blood HDL levels e. decrease blood HDL levels
increase blood HDL levels
40
Dupuytren’s contracture is caused by Select one: a. scarring of the flexor tendons b. scarring of flexor policis brevis c. scarring of the palmar fascia d. scarring and swelling of the tendon sheath e. scarring of flexor policis longus
scarring of the palmar fascia