Foundations in Immunology Flashcards Preview

Science for Medicine > Foundations in Immunology > Flashcards

Flashcards in Foundations in Immunology Deck (16):

What are the major cells involved innate immunity?

- macrophages
- neutrophils


What are the major cells involved in adaptive immunity?



What is the main role of the innate immune system

To act as the body's first line of defence


What are the physical barriers of the innate immune system?

- tight junctions between epithelia
- mucous membranes


What phagocytic cells are in the innate immune system?

- macrophages
- neutrophils


What are the three defences of the innate immune system?

- physical barriers
- phagocytic cells
- soluble factors


Describe the process of phagocytosis

Phagocytosis is triggered when the phagocyte recognises a foreign cell
- it is the internalisation of foreign matter by cells into cytoplasmic vesicles
- once inside, the matter is digested by lysosomes which contain enzymes


The digestion of foreign cells by lysosomes also kills

the cell that did the ingesting


What are the primary lymphoid organs?
What is their function?

These organs are where lymphocytes are generated
- thymus
- bone marrow
- foetal liver


What are the secondary lymphoid organs?
What is there function?

Where immune responses are initiated and lymphocytes maintained
- lymph nodes
- spleen


What are the four fundamental properties of an adaptive immune response?

- specificity
- diversity
- memory
- recruitment of other defence mechanisms


What is the role of B-lymphocytes in immunity?

B-cells differentiate further to form plasma cells
- these cells synthesise antibodies specifically designed for use against detected pathogen
- pathogen recognised by membrane bound antibody
- antibodies produced by plasma cells are soluble in plasma


The section of an antibody which binds to the antigen is the

paratope and binds to the antigen epitope


Antigens are proteins which are able to

evoke an immune response and react with immune products


The complement system is made up of

25 serum proteins whose sequential activation and assembly into functional unit can bring about three events


What three events can be brought about by the activation of the serum proteins of the complement system?

- recruitment of inflammatory cells
- coating/opsonisation of bacteria
- lysis of bacteria