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Flashcards in Foundations in Immunology Deck (16):
1

What are the major cells involved innate immunity?

- macrophages
- neutrophils

2

What are the major cells involved in adaptive immunity?

Lymphocytes

3

What is the main role of the innate immune system

To act as the body's first line of defence

4

What are the physical barriers of the innate immune system?

- tight junctions between epithelia
- mucous membranes

5

What phagocytic cells are in the innate immune system?

- macrophages
- neutrophils

6

What are the three defences of the innate immune system?

- physical barriers
- phagocytic cells
- soluble factors

7

Describe the process of phagocytosis

Phagocytosis is triggered when the phagocyte recognises a foreign cell
- it is the internalisation of foreign matter by cells into cytoplasmic vesicles
- once inside, the matter is digested by lysosomes which contain enzymes

8

The digestion of foreign cells by lysosomes also kills

the cell that did the ingesting

9

What are the primary lymphoid organs?
What is their function?

These organs are where lymphocytes are generated
- thymus
- bone marrow
- foetal liver

10

What are the secondary lymphoid organs?
What is there function?

Where immune responses are initiated and lymphocytes maintained
- lymph nodes
- spleen

11

What are the four fundamental properties of an adaptive immune response?

- specificity
- diversity
- memory
- recruitment of other defence mechanisms

12

What is the role of B-lymphocytes in immunity?

B-cells differentiate further to form plasma cells
- these cells synthesise antibodies specifically designed for use against detected pathogen
- pathogen recognised by membrane bound antibody
- antibodies produced by plasma cells are soluble in plasma

13

The section of an antibody which binds to the antigen is the

paratope and binds to the antigen epitope

14

Antigens are proteins which are able to

evoke an immune response and react with immune products

15

The complement system is made up of

25 serum proteins whose sequential activation and assembly into functional unit can bring about three events

16

What three events can be brought about by the activation of the serum proteins of the complement system?

- recruitment of inflammatory cells
- coating/opsonisation of bacteria
- lysis of bacteria