Essential Pharmacology Flashcards Preview

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Flashcards in Essential Pharmacology Deck (12):
1

What are the basic functions of receptors?

- enable specificity
- evoke an appropriate response

2

What is a receptor?

A protein that recognises a specific compound or molecule
- this can result in the triggering of a massive variety of effects
- or can in some cases inhibit the effects of the proteins and chemicals

3

What do agonists do?

Mimic the normal effect of a receptor

4

What do antagonists do?

Block the normal action of a receptor

5

Describe the relationship between agonist concentration and effect

Increasing conc. of agonist will mean more receptors are occupied by it so the effect increases
- this only works up to a certain point where all of the receptors become saturated and there are no longer free ones for the agonist to bind to

6

What is affinity?

The strength of the chemical attraction between the drug and receptor

7

What is the efficacy of an agonist?

How good an agonist is at activating the particular receptor

8

What are the four types of membrane receptors?

- receptors that act as ion channels
- receptors with intrinsic enzyme activity
- receptors that interact with JAK kinases
- receptors that interact with G-proteins

9

What is the largest family of membrane receptors?

G-protein receptors

10

What happens when G-protein receptors are couples to Adenylyl Cyclase?

- increases/decreases conc. of cAMP
- activates/inhibits PKA

11

What happens when G-protein receptors are coupled to Phospholipase C?

- produces diacylglycerol and inositol triphosphate
- activates PKC and releases internal Ca2+ stores

12

What are the sources on intracellular calcium?

- from internal stores via calcium triggered release from endoplasmic reticulum
- from outside the cell via ligand-gated or voltage-gated channels
- via inhibition of Ca2+ transport out of the cell