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Flashcards in Functions of inhibitors Deck (10):
1

What is the function of α-amanitin?

Poison. Interferes with RNAPII in prokaryotes by disrupting translocation of RNA-DNA complex through structure.

2

What is the function of actinomycin D?

Chemothrapeutic agent. Intercalates into DNA and prevents initiation of transcription.

3

What is the function of rifamycin?

Antibiotic. Binds to prokaryotic RNAP and inhibits bacterial transcription (probably blocks chain elongation by binding to β-subunit).

4

What is the function of ricin?

Glycosidase activity removes adenosine from 28S RNA, inactivating ribosome and thus inhibiting translation.

5

What is the function of diptheria toxin?

Inhibits activity of eEF-2, preventing ribosomal translocation on mRNA and thus translation.

6

What is the function of streptomycin?

- Antibiotic
- At high concentrations, it binds to and inhibits 30S subunit of bacterial ribosome
- At lower concentrations, it causes misreading of mRNA

7

What is the function of tetracycline?

- Antibiotic
- Inhibits binding of aminoacyl-tRNA to bacterial 30S subunits.

8

What is the function of oxazolidines?

- Antibiotic
- Inhibits formation of Met-tRNAi-30S initiation complex

9

What is the function of chloramphenicol?

- Antibiotic
- Inhibits peptidyl transferase activity of 50S subunit

10

What is the function of erythromyocin?

- Antibiotic
- Binds to 50S subunit at the exit tunnel of free tRNA molecules and prevents them from being released. This blocks the progression of ribosome complex.