Fungal and parasitic infections of the CNS Flashcards Preview

Year 1 Microbiology > Fungal and parasitic infections of the CNS > Flashcards

Flashcards in Fungal and parasitic infections of the CNS Deck (26):
1

What are the five fungi that have potential to cause systemic infections?

1. Histoplasma 2. Blastomyces 3. Paracoccidioides 4. Coccidioides 5. Cryptococcus

2

What is the leading cause of fungal meningitis?

Cryptococcal meningitis

3

Which fungus is yeast in both environment and tissues?

Cryptococcus neoformans

4

Which fungus is dimorphic?

Coccidioides immitis

5

Which fungus has a spherule as part of its development?

Coccidiodes immitis - spherule in tissues

6

What is the treatment for coccidial meningitis?

Amphotericin B

7

What is the treatment for cryptococcal meningitis?

6-10 weeks with Amphotericin B and 5-fluorocytosine / fluconazole

8

What are the zygomycetes?

Rhizopus, absidia, mucor

9

What is the morphology of the zygomycetes?

Broad, aseptate hyphae and sporangia bearing sporangiophores

10

Which fungal infection is seen primarily in diabetic patients?

Rhinocerebral zygomycosis

11

Rhinocerebral zygomycosis is seen mostly in what population?

Diabetic

12

Entamoeba histolytica is associated with what condition?

Brain abscess

13

Trypanosoma brucei is associated with what condition?

Sleeping sickness

14

Plasmodium falciparum is associated with what condition?

Cerebral malaria

15

What are the three free-living amoeba?

Acanthamoeba, naegleria, balamuthia

16

What causes primary amebic meningoencephalitis?

Naegleria fowleri

17

Naegleria fowleri is typically seen in what environments?

1. Mostly in southern states 2. Hot tubs 3. Neti pots

18

What causes granulomatous amoebic encephalitis?

Acanthamoeba and balamuthia

19

Acanthamoeba keratitis is mostly seen in what type of condition?

Chronic infection of cornea - associated with contact lens use

20

What is the lifecycle of toxoplasma gondii?

1. Sporozoan parasite that reproduces in gut of cats 2. Oocysts contaminate food

21

What indicates acute infection during prenatal toxoplasma gondii testing?

IgM or rising IgG titer

22

Ingestion of encysted taenia solium larvae results in what condition?

Intestinal disease

23

Ingestion of embryonated taenia solium eggs results in what condition?

Extra-intestinal disease

24

Neurocysticercosis is a complication from what disease?

Taenia solium (pork tapeworm) extra-intestinal infection

25

What is visceral larval migrans?

Infection of man by ascarid worms which normally infect dogs and cats

26

What are the common migration sites for visceral larval migrans?

Granulomatous lesions in liver, spleen, lung, and eye