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Y1 MCD Microbiology > Fungal infection > Flashcards

Flashcards in Fungal infection Deck (8)
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1

What are the main differences between fungi and bacteria?

Fungi are:
-Saprophytes
-Spread via spores over long distances
-Eukaryotic
-Have a membrane bound nucleus
-Cell wall
-DNA vs RNA

2

What effect do the differences between fungi and bacteria have on treatment for fungal infections?

Fungal infections harder to treat

3

What are the 3 main types of fungal infection?

Allergy
Mycotoxicoses
Mycoses

4

What is an example of a fungal allergy and how do they occur?

e.g. Asthma, rhinitis, dermatitis
Sensitisation to the spores causes allergic reaction

5

What is an example of a mycotoxicosis and how do they occur?

e.g. Psilocybin, aflatoxin
Inhalation/ingestion of a mycotoxin (2° metabolite of mould)
Typically eating poisonous mushrooms
Can cause carcinomas (aflatoxin)

6

Define superficial mycoses and give an example

Fungal infection of the outermost layers of skin/hair
e.g. Tinea capitis/dandruff

7

What are the 3 major classes of anti-fungal drugs?

Classed by their target
Cell membrane - target ergosterol production
e.g. Polyene antibiotics, azole antifungals
DNA synthesis
e.g. Pyramidine analogues, used in combination therapy
Cell wall
e.g. Echinocandins

8

Define deep mycoses and give an example

Fungal infection that occurs via GI, IV devices, catheter
Are opportunists and typically require a compromised host
e.g. Coccidioides immitis