Flashcards in Fungal infection Deck (8)
What are the main differences between fungi and bacteria?
-Spread via spores over long distances
-Have a membrane bound nucleus
-DNA vs RNA
What effect do the differences between fungi and bacteria have on treatment for fungal infections?
Fungal infections harder to treat
What are the 3 main types of fungal infection?
What is an example of a fungal allergy and how do they occur?
e.g. Asthma, rhinitis, dermatitis
Sensitisation to the spores causes allergic reaction
What is an example of a mycotoxicosis and how do they occur?
e.g. Psilocybin, aflatoxin
Inhalation/ingestion of a mycotoxin (2° metabolite of mould)
Typically eating poisonous mushrooms
Can cause carcinomas (aflatoxin)
Define superficial mycoses and give an example
Fungal infection of the outermost layers of skin/hair
e.g. Tinea capitis/dandruff
What are the 3 major classes of anti-fungal drugs?
Classed by their target
Cell membrane - target ergosterol production
e.g. Polyene antibiotics, azole antifungals
e.g. Pyramidine analogues, used in combination therapy