Funguses

Question 1

Note predisposing factors to fungus involves

AB use; IV use;
NEUTROPENIA ; transplant; steroids; AIDs

Answer 1

ok

Question 2

Candida - dimorphic
- Candida albican has germ tube

Give 2 Systems infected;
Give 2 drugs

Answer 2

• note can infect heart
• pericarditis, pericarditis
• superimposed endocarditis from IV use
• candiuria from AB use, catheter;
• • can just remove AB, catheter no need antifungal

Fluconazole
AmB + Nyastatin

Question 3

Cryptococcus

• location
• type
• diagnosis
• pathology presentation
• first line?

Answer 3

• soil, bird droppings
• encapsulated yeast
• india ink; antigen both in CSF
• cryptococcoma - form ball
• • meningitis, lung

AmB + 5 FC
- faster than IV fluconazole

Question 4

Aspergillus - mold, form filaments

• lung can form ball too;
• first line?

Answer 4

Voriconazole IV;

Question 5

trichosporon are yeasts;

- NOT part of dermatophye group

Answer 5

ok

Question 6

Dermatophye group

• what do they cause; what are they
• name a superficial drug for it
• name their transmissions

Answer 6

skin hair nail infection from Keratin as nutrients;

• tinea; onychomycoses
• • Terbinafine!

They are MOLDS - branching filaments
- Sabouraud Dextrose Agar Agar; use macroconidia to separate

Trichophyton - human to human
Micosporum - animal dog cat
Epidermophyton - h2h

Question 7

Whats malassezia

- Type, associated infection

Answer 7

malassezia FURFUR

• yeasts;
• tinea versicolor (white lesions on skin)

Question 8

Trichophyton

- Type, associated infection

Answer 8

Mould;

White Piedra on hair;

Question 9

Lab investigation of

• Candida
• Cryptococcus
• Aspergillus

Answer 9

Sabouraud Dextrose Agar

Dimorphic - Germ tube
Yeast - India Ink, CSF antigen
Mold - Galactomannan antigen assay

Question 10

Pneumocystis jirovecii

-what drug to give

Answer 10

Yeast
Cannot be cultured
Silver stain; PCR

AIDs patient;
Co-trimoxazole