Virus III - MMR

Question 1

Measles

• genome, spread
• presentation

Answer 1

ssRNA, YES enveloped
Respiratory;

Fever, runny nose, cough
Kolpik's spots around opening of parotid duct
- BEFORE rash
Maculopapular rash
- spreads away to body

Mucosal infection
Respiratory infection
GI infection
CNS, encephalitis

Question 2

Mumps

• genome, spread
• presentation
• Cx

Answer 2

same family as measles

• ssRNA, yes
• respiratory

Parotitis - parotid gland swelling;
Cervical lymphadenopathy

• possible Orchitis

Question 3

Rubella

• genome, spread
• presentation
• Cx

Answer 3

ssRNA, YES
- respiratory

also Maculopapular Rash
- outward movement
ROSE SPOTs in mouth, palate VS Kolpiks spots
throat inflammation

• Thrombocytopaenia and Haemorrhage
• Arthralgia

Question 4

Note rubella and measles

• both maculopapular rash w outward spread
• differ in spots

MMR vaccine live attenuated;

Answer 4

okie

Question 5

Congenital Rubella

• worse when
• presentation

Answer 5

Worse early

• CNS microcephaly // CVS problem
• CN8 deafness - sensorineural
• ocular lesions - cataracts, retinopathy

other systemic shit;

Question 6

Congenital rubella vs syphillis

Answer 6

Syphilis is the one w Hutchinson’s Triad

• notched teeth
• CN8
• Keratitis

Here is

• CN8
• Ocular
• CNS / CVS

Question 7

Parvovirus

• genome, spread
• pathology, cell target
• 3 groups of Px

Answer 7

think Parvovirus B19
- 5th disease

ssDNA, NO envelop - simplest DNA virus
body fluids

• Fifth Disease (Erythema Infectiosum) (slapped cheek, or lacy reticulated)
• TARGETS HUMANS ERYTHROID PROGENITOR CELLS causes lysis of cells leading to anaemia. Can also affect lymphocytes, granulocytes and platelets.
• transient Bone Marrow Suppression
• Immunocompromised - aplastic crisis
• Chronic anemic px - aplastic crisis
• Pregnant - non immune hydrops fetalis

Question 8

Poxvirus

genome, vs Herpes structure
names

Answer 8

Smallpox - variola
Cowpox - vaccinia
Molluscum contagiosum

Think large
- DS DNA, YES ENVELOPED
Herpes is dsDNA, YES enveloped

Question 9

Rabies virus

genome

• pathology
• histology
• vaccine?

Answer 9

Zoonose

ssRNA, enveloped

Prodromal - irritability, hydrophobia
– painful spasms of the muscles in the throat and larynx
Excitatory - seizures, hyperactivity
Paralytic - eventually respi and CVS;

Negri bodies
Yes vaccine, whole inactivated

Question 10

Prions

note not antigenic - hence immunosuppression useless

what isit
how spread
whats teh disease
pathology appearance
diagnosis

Answer 10

misfolded proteins with the ability to transmit their misfolded shape onto normal variants of the same protein

contaminated transplant; EEG electrodes

CJD
- myoclonic jerks

• spongiform appearance, CNS vacuolated neurons
  14 3 3 protein in CSF
  EEG periodic sharp waves complex

Question 11

Note which are the DNA viruses
- do they have envelops

Note Enterovirus ssRNA not enveloped

Answer 11

DNA

• dsDNA: herpes, POX
• ssDNA: parvovirus B19

Herpes YES
POX YES
B19 NO

Question 12

HIV

• genome, envelop?
• membrane and capsid markers?
• seroconversion period
• critical point of CD4
• Lab diagnosis
• transmission

Answer 12

2 ssRNA, enveloped

p17 membrane, p24 capsid

• 6 months
• 200cells/mm3 CD4

ELISA plus p24 (note ELISA AB seroconversion 6 months)
- must confirm w western blot

Vertical can;
Mucous membrane and blood contact is needed;
- breast milk yes, saliva no, pre cum no