GBP3

Question 1

What does Css mean

Answer 1

Concentration at a steady state, rate in=rate out

Question 2

What is a maintenance dose equal to

Answer 2

amount removed from the body during Css

Question 3

What problems might there be with a fast oral drug

Answer 3

Can have toxic side effects

Question 4

What problems might there be with a slow oral drug

Answer 4

Effective half life prolonged and prolongs action of the drug = functional half life

Question 5

How many half lives does it take to achieve a steady state

Answer 5

approx. 5

Question 6

What are three important measures when deciding an oral regimen

Answer 6

Therapeutic window
Urgency of onset of effect
Elimination half-life

Question 7

Give an example of a drug with

a) a large TW
b) a small TW

Answer 7

a) penicillin

b)

Question 8

What would be the dosage strategy for a drug with

a) moderate half life
b) long half life

Answer 8

a) initial does then half that every half-life

b) set 24hour dosage interval to ensure best pt compliance