GBP6 Flashcards
(15 cards)
Define bioequivalence
identical rate and extent of absorption
How is bioequivalence assessed?
tmax (time to max plasma level)
cmax (peak plasma level)
f (bioavailability)
Why are modified or sustained release preparations used
reduce rate of absorption and prolong action
deliver drug to specific region of GI tract
What is oramorph used for
break through pain, oral suspension for immediate pain relief
What is Nifedipine
DHP calcium channel inhibitor, used in hypertension and angina
Why is Nifedipine only used in sustained release forms
Immediate release associated with increased cardiac events
Why is omeprazole given in acid resistant tablets
Because it is an acid labile drug, so is broken down in the stomach and rendered useless, the enteric coating means the capsule is degraded at ph 5-6 in the duodenum, where it is absorbed and can travel via circulation to the stomach, activated by low ph
When are skin patches useful
Sustained release, and when a patient cant swallow a tablet
Why might depot injections be useful
to aid compliance
absorption of thick oils
avoid first pass metabolism
Which drugs are expressed as percentage solutions
local anaesthetics, some eyedrops
What does a percentage solution mean
Means grams per 100ml of solution
What does 1% solution mean
1g per 100ml or 100mg per 10ml or 10mg per ml
What does 0.1% solution mean
0.1g or 100mg per 100ml, 10mg per 10ml, 1mg per ml
What is adrenaline supplied in
1:1000 1mg/ml
What are biological units?
a measure of biological activity
