General Pharm (Chemo/Alkylating&Hormones/Anti-Metabolites)

Question 1

Gompertzian Growth

Answer 1

tumor takes constant amount of time to double its size

Question 2

Goldie-Coldman Hypothesis

Answer 2

best strategy prevention of tumor resistance is to initiate treatment early and use a combination of drugs with non-overlapping toxicities

Question 3

Partial response to anti-cancer

Answer 3

reduction of at least 50% in the diameter of all measurable lesions

Question 4

Stable disease

Answer 4

range from decrease of < 50% to increase of < 25% in diameter product of tumor

Question 5

Progressive disease

Answer 5

increase of more than 25% in diameter product of any lesion

Question 6

cell-cycle non-specific

Answer 6

alkylators
platinums
anthracyclines

Question 7

M-phase

Answer 7

vinca alkaloids

taxanes

Question 8

S-phase

Answer 8

antimetabolites

Question 9

vinca alkaloids

Answer 9

vincristine, vinblastin

Question 10

taxanes

Answer 10

paclitaxel

docetaxel

Question 11

vomiting center (medulla) receives input from

Answer 11

GI tract, cerebral cortex, vestibular apparatus, chemoreceptor trigger zone (CTZ)

Question 12

NTs of emetic reflex

Answer 12

dopamine
histamine
serotonin
endorphins
ACh
GABA
Substance P

Question 13

acute anti-emetics

Answer 13

serotonin antagonists
nk-1 antagonists
corticosteroids

(first 24hr)

Question 14

delayed anti-emetics

Answer 14

DA antagonists
corticosteroids
nk-1 antagonists

(3-5d post chemo, assoc w/ cisplatin,
cyclophosphamide,
doxorubicin)

Question 15

anticipatory anti-emetics

Answer 15

benzos

Question 16

5-HT3 antagonists - anti-emetics

Answer 16

odansetron*
palonosetron*
dolasetron
granisetron

Question 17

corticosteroid anti-emetics

Answer 17

dexmethasone

Question 18

atypical antipsychotic - anti-emetics

Answer 18

olanzapine

Question 19

benzos - anti-emetics

Answer 19

lorazepam

Question 20

EPO to tx anemia

Answer 20

procrit

darbepoetin

Question 21

myeloid growth factors to lessen neutropenia

Answer 21

filgrastim (GCSF)
sargamostim (GM-CSF)
pegfilgrastim (long-acting GM-CSF)

Question 22

alkylating agents

Answer 22

platinum analogues

• cisplatin
• oxaplatin
• carboplatin

Cyclophosphamide

Ifosfamide

Question 23

Hormonal agents - anti-cancer

Answer 23

Glucocorticoids

Androgens

Question 24

Anti-hormonal agents

Answer 24

• aromatase inhibitors
• anti-estrogen
• anti-androgen
• LH-RH agonists

Question 25

platinum analogues

Answer 25

- cisplatin - oxaplatin - carboplatin

Question 26

standard of care w/ ifosfamide admin

Answer 26

MESNA | binds acrolein in urine

Question 27

acrolein

Answer 27

metabolite of cyclophosphamide and ifosfamide bladder toxicity

Question 28

nitrogen mustards

Answer 28

cyclophosphamide | ifosfamide

Question 29

anti-androgens

Answer 29

flutamide bicalutimide nilutamide

Question 30

LHRH agonists

Answer 30

leuprolide goserelin triptorelin

Question 31

anti-estrogens

Answer 31

tamoxifen raloxifene toremifine fulvestrant

Question 32

aromatase inhibitors

Answer 32

anastrazole letrozole exemestane

Question 33

glucocorticoids - anti-cancer

Answer 33

prednisone

Question 34

androgens

Answer 34

dihydrotestosterone | danazol

Question 35

anti-metabolites

Answer 35

methotrexate cytarabine 5-FU gemcitabine

Question 36

methotrexate reversal agent

Answer 36

leucovorin (colonic acid)

Question 37

glucarpidase

Answer 37

enzyme that rapidly cleaves methotrexate into non-toxic form

Question 38

Ara-C

Answer 38

Cytarabine | anti-metabolite

Question 39

5-FU has synergistic effects w/ _____

Answer 39

5-FU has synergistic effects w/ LEUCOVORIN

Question 40

3 intrathecal drugs

Answer 40

methotrexate cytarabine thiotepa

Question 41

other antimetabolites

Answer 41

6-mercaptopurine 6-thioguanine capecitabine pemetrexed - anti-folate

Question 42

dopamine antagonists

Answer 42

procholoperazine metoclopramide perphenazine

Question 43

adjuvant

Answer 43

used after deqnitive solid surgery to eradicate micro-metastatic disease

Question 44

Neoadjuvant

Answer 44

used to reduce tumor burden prior to surgical intervention