Random

Question 1

Individuals with inherited prothrombotic disorders often have their first thrombosis

Answer 1

during their teen years or early twenties

Question 2

Activated Protein C resistance (Factor V Leiden) mutation

Answer 2

Missense mutation of Arginine 506 to Glutamine 506 (Arg-506-Gln)

Question 3

Prothrombin gene mutation

Answer 3

G to A substitution of nucleotide 20210 in 3’ untranslated portion of the gene

Question 4

anti-phospholipid Ab syndrome MOA

Answer 4

production of antibodies against proteins which interact with phospholipid within cell membranes such as the endothelium of the vasculature

causes activation of the endothelial lining and increases risk for thrombosis

same antibodies interact in vitro with the phospholipid used in coagulation screening tests such as the PTT. Despite a prolongation in the PTT, there is no clinical bleeding.

Question 5

p-selectin

Answer 5

enhances activation of platelets and leukocytes which play a key role in the inflammatory process

mediates the adhesion of activated platelets to monocytes and neutrophils

Question 6

Fever and sepsis most commonly develop after transfusion with

Answer 6

platelets are the most common source, as they are the only blood product stored at room temperature

Question 7

sickle cell pt with hemolysis, avoid what in tx?

Answer 7

rbc transfusions, don’t want hyperhemolysis

Question 8

Malignant transformation of immature progenitor cells within ____ gives rise to acute lymphocytic leukemia.

Answer 8

the bone marrow

Question 9

Malignant transformation of B cells going through developmental stages within _____ gives rise to lymphomas.

Answer 9

lymph nodes

Question 10

MCV in 60s

Answer 10

thalassemia until proven other wise

Question 11

Two classes of cytotoxic chemotherapy drugs are associated with treatment-related AML

Answer 11

alkylating agents

topoisomerase II inhibitors

Question 12

Alkylator-associated AML

Answer 12

deletions of chromosome 5/5q or 7/7q

Question 13

topo II inhibitor-associated AML

Answer 13

balanced translocations involving the MLL gene at 11q23

Question 14

good prognostics AML

Answer 14

t(8;21) and t(15;17)

CBF

Question 15

poor prognostics AML

Answer 15

MLL (11q23) - topo II related

5/7 deletions - alkylator related

> 3

Question 16

target cells

Answer 16

think mostly thal

could also be HbC

Question 17

HbSC

Answer 17

one sickle

one C

Question 18

HbCS

Answer 18

alpha thal

Constant Spring mutation (longer mRNA transcript)

Question 19

good prognostics ALL

Answer 19

t(12;21)
hyperploidy
nml cytogenetics
1-9 y/o, female

Question 20

bad prognostics ALL

Answer 20

t(9;22)
11q23
hypOploidy
t(4;11)
infants/adults

Question 21

acute myeloid leukemia

leukemic blasts express…

Answer 21

CD13, CD33

Question 22

constitutional symptoms, anemia, lymphocytosis, and thrombocytopenia with resulting petechiae and bleeding

Answer 22

acute leukemia

Question 23

acute leukemia more common in kids

Answer 23

ALL

peak at 4 y/o

Question 24

acute leukemia more common in adults

Answer 24

AML

Question 25

t(14;18)

Answer 25

follicular NHL bcl2 activation

Question 26

hyp__calcemia in tumor lysis syndrome

Answer 26

hypOcalcemia (phosphate precipitates w/ ca)

Question 27

dabingatran

Answer 27

prophylaxis of stroke w/ afib

Question 28

CHOP

Answer 28

cyclophosphamide, doxorubicin, vincristine and prednisone

Question 29

hepatitis B reactivation

Answer 29

rituximab

Question 30

delayed N/V

Answer 30

Cyclophosphamide, cisplatinum, and doxorubicin

Question 31

non-specific cell cycle chemo

Answer 31

alkylators platinums anthracyclines

Question 32

long term effects of _____ include sterility and increased risk of secondary leukemias

Answer 32

alkylating therapy

Question 33

danazol

Answer 33

androgen suppresses gonadotrophin production and has pro-androgenic effects through direct action on the androgen receptor

Question 34

androgen-inhibitors are mainly used to treat

Answer 34

PROSTATE CANCERS

Question 35

_______ are begun prior to initiation of GnRH analogs specifically to block “tumor flare” induced by the initial increase in androgen synthesis.

Answer 35

Androgen receptor inhibitors (bicalutamide, flutamide)

Question 36

____ does prolong survival in CML but at the cost of unpleasant side effects

Answer 36

Interferon alpha

Question 37

______ is the only curative treatment currently available for CML, but is associated with significant morbidity and mortality

Answer 37

Allogeneic HSCT

Question 38

T/F EBV is associated w/ hepatocellular carcinoma

Answer 38

F

Question 39

T/F Sources of stem cells for hematopoietic transplantation include irradiated wbc

Answer 39

F

Question 40

cryoglobinemia is associated with which virus

Answer 40

hep C

Question 41

5q syndrome has a better prognosis for

Answer 41

MDS

Question 42

autologous transplant

Answer 42

malignant and autoimmune