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Flashcards in General Principles 2 Deck (12)
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1
Q

Cytochrome P 450 Inducers

A
PREG CBS
Phenytion
Rifampin
Ehambutol
Griseofulvin

Carbamazepine
Barbutuates
St. Johns wort

2
Q

CYP450 Inhibitors

A
SICK RAGE Q
Sulfonamides
Isoniazide
Cimetidine
Ketoconazole
Ritonavire
Amiodarone
Grapefruit juice
Erythromycin
Quinidine
3
Q

Route with 100% bioavailability

A

IV

4
Q

First pass effect

A

Oral

5
Q

Partial avoidance of first pass effect

A

Rectal

6
Q

Application to skin for local effect

A

Topical

7
Q

Application to skin for systemic effect

A

Transdermal

8
Q

Phase with small number of normal volunteers

A

Phase 1

9
Q

Post-marketing surveillance phase

A

Phase IV

10
Q

“Does it work with patients?”

A

Phase II

11
Q

Randomized, double blind, controlled studies

A

Phase III

12
Q

A drug for a rare disease

A

Orphan drug