GeneticsCYP-EO

Question 1

What is the heritability of GAD

Answer 1

30%

Question 2

What is risk ratio of 1st degree relative with GAD to gen pop

Answer 2

6 x

Question 3

What is risk ratio of 1st degree relative with ADHD to gen pop

Answer 3

2-8

Question 4

What is risk ratio of 1st degree relative with schizophrenia to gen pop

Answer 4

10

Question 5

What is risk ratio of 1st degree relative with BAD to gen pop

Answer 5

7-10

Question 6

What is risk ratio of 1st degree relative with MDD to gen pop

Answer 6

3

Question 7

What is risk ratio of 1st degree relative with OCD to gen pop

Answer 7

4

Question 8

What is the heritability of schizophrenia

Answer 8

50-89

Question 9

What is the heritability of BAD?

Answer 9

60-85

Question 10

What is the heritability of MDD?

Answer 10

40

Question 11

What is the heritability of OCD?

Answer 11

30-45

Question 12

What is the heritability of ADHD?

Answer 12

75%

Question 13

What is the prevalence of SUD in:
1 ASPD
2 BAD
3 Scz
4 MDD

Answer 13

1 -84%
2 -56%
3 -47%
4- 27%

Question 14

What is the RR of substance use if:
One parent has SUD?
2 parents have SUD?
Father has ETOH and criminality?

Answer 14

2-4 for one parent
2-10 for 2 parents
9-18 if father

Question 15

which antidepressant is a 2D6 substrat?

Answer 15

fluvoxamine
Prozac
Paxil
Sertraline
Duloxetine
Venlafaxine
Mirtazapine
Trazodone
Vortioxetine
TCA (secondary and tertiary amines)

Question 16

Which antipsychotics is a substrate of 2D6?

Answer 16

Haldol
Olanzapine
Risperidone
Aripiprazole
FGA

Question 17

Which psychostimulants are substrate of 2D6?

Answer 17

Amphetamines (dexedrine and adderall)

Atomoxetine

Question 18

Which class other than psychotropics are substrat of 2D6

Answer 18

Opioids (codeine methadone morphine)
B-blockers
Tamoxifen

Question 19

Which meds are inducers of 2D6?

Answer 19

Rifampin
Phenytoin
Carbamaxepine

Question 20

Which antidepressants are 2D6 inhibitors?

Answer 20

Prozac
Paxil
Dulox
buproprion
Sertraline
es/citalopram
TCA (tertiary and secondary amines)

Question 21

Which antipsychotics are 2D6 inhibitors?

Answer 21

Abilify
Risperidone
Haldol

Question 22

Which meds other than psychotropics are 2D6 inhibitors?

Answer 22

CBD
Cocaine
Methadone
Amiodarone
Quinidine
Terbinafine

Question 23

Which antidepressant is a 3A4 substrat?

Answer 23

Sertraline
Fetzima
Vilazodone
Buspirone
Trazodone
TCA tertiary amines

Question 24

Which antipsychotics are 3A4 substrats?

Answer 24

Abilify
Lurasidone
Seroquel
Ziprasidone
Haldol
Clozapine (less than 1A2)

Question 25

Which bezos are 3A4 substrats?

Answer 25

Alprazolam | Diazepam

Question 26

Which meds other than psychotropics are 3A4 substrats?

Answer 26

``` Oxy Cocain Fentanyl Statines Tamoxifen ```

Question 27

Which meds are 3A4 inducers?

Answer 27

``` St-John wart Modafinil Rifampin Phenytoin Phenobarb Carbamazepine/oxcarbamazepine Prednisone/glucocorticoids HIV meds Topamax ```

Question 28

What inhibits 3A4?

Answer 28

``` Fluvoxamine Jus de pamplemousse Amiodarone Antifungals (azoles) THC/CBD HIV meds Macrolides (clarythro) ```

Question 29

Which antidepressants are 1A2 substrats?

Answer 29

Fluvoxamine Agomelatine Mirtazapine TCA (tertiary - clomi, amitr, imi)

Question 30

Which antipsychotics are 1A2 substrats?

Answer 30

Clozapine Haldol Olanzapine

Question 31

What other substance are 1A2 substrat?

Answer 31

Café Warfarine Methadone Acetaminophene

Question 32

Which susbstance induce 1A2?

Answer 32

``` Cigarette BBQ Modafinil Insuline Marijuana Choux de bruxelle Broccoli Phenytoine Rifampin Rifampin ```

Question 33

Which substance inhibits 1A2?

Answer 33

Fluvox Cimetidine Amiodarone Fluoroquinolones (cipro)