Genital Infections

Question 1

How are genital infections commonly transmitted?

Answer 1

STDs

Question 2

What conditions can Neisseria gonorrhoeae cause as it ascends the genital tract?

Answer 2

• Acute endometriosis
• Acute Salpingitis
• Tuboovarian Abscesses

Question 3

What is syphilis caused by?

Answer 3

Treponema pallidum

Question 4

What are the stages of syphilis and the characteristically associated lesions?

Answer 4

1. Primary - chancre
2. Secondary - Condylomata lata
3. Tertiary - Cardiovascular and Nervous System

Question 5

What is the histological hallmark of syphilis?

Answer 5

Dense inflammatory infiltrate with lymphocytes and plasma cells/Spirochetes ID’ed with silver impregnation stains

Question 6

What bug causes granuloma inguinale?

Answer 6

Calymmatobacterium granulomatis

Question 7

What is the histological finding of granuloma inguinale?

Answer 7

Donovan bodies

Question 8

What is chancroid caused by?

Answer 8

Haemophilus ducreyi

Question 9

What is gardnerella caused by? What is pathognomonic for the disease?

Answer 9

Gardnerella vaginalis; Clue cells - squamous cells covered by coccobacilli

Question 10

What bug causes Chlamydia?

Answer 10

Chlamydia trachomatis

Question 11

What morphology is seen in uscopy of Chlamydia infection?

Answer 11

Perinuclear intracytoplasmic inclusions with distinct borders and intracytoplasmic coccoid bodies

Question 12

What is Lymphogranuloma Venereum caused by?

Answer 12

Chlamydia trachomatis serotypes L1 thru L3

Question 13

What are the typical lesions of a person with HPV?

Answer 13

Verrucae and condylomata

Question 14

What serotypes of HPV account for over 80% of visible condylomata?

Answer 14

Serotypes 6 to 11

Question 15

What type of lesion does HPV cause?

Answer 15

Condylomata Acuminatum

Question 16

HPV is shown. What are the characteristic lesions?

Answer 16

Koilocytes - epithelial cells with a perinuclear halo and wrinkled nucleus containing HPV particles

Question 17

What is the typical bug that causes genital herpes?

Answer 17

HSV2

Question 18

What are the typical histo characteristics of molluscum contagiosum?

Answer 18

Molluscum bodies - Large cytoplasmic viral inclusions

Question 19

What bug causes trichomoniasis?

Answer 19

Trichomoniasis vaginalis

Question 20

What is pelvic inflammatory disease?

Answer 20

PID is infection of pelvic organs due to extension of any of a variety of uorganisms beyond the uterine corpus

Question 21

What are the typical culprits of PID?

Answer 21

N. gonorrhoeae and C. trachomatis

Question 22

What are complications of PID?

Answer 22

1. Rupture of tuboovarian abscess
2. Infertility from scarring
3. Increased rate of ectopic pregnancy
4. Intestial obstruction from fibrous bands

Question 23

What generally is the initial lesion of genital tuberculosis?

Answer 23

Tuberculous salpingitis

Question 24

What are late sequelae of tuberculous salpingitis?

Answer 24

Pyosalpinx and hydrosalpinx

Question 25

What is the typical presentation of Candidiasis?

Answer 25

Vulvar itch and white discharge

Question 26

What bug causes sulfur granules and is associated with IUD use?

Answer 26

Actinomyces israelii

Question 27

What is toxic shock syndrome caused by?

Answer 27

S. aureus that release the exotoxin toxic shock syndrome toxin-1 which inhibits the ability of mononuclear phagocytes to clear other toxins