Geriatric PK/PD: Distribution Flashcards
Body composition: decreased lean body mass results in ________ levels.
Results in decreased digoxin levels
Body composition: increased fat results in ________, which extends _______.
Increased fat results in the increased Vd of BZDs, which extends its half-life
Body composition: decreased water results in ________, which _______ concentrations of _________________.
Decreased water results in decreased Vd, which increases concentrations of lithium, theophylline, AGs, and ethanol.
Albumin in healthy patients
No significant change
Albumin decreases in what?
underlying, severe, or chronic illnesses
Albumin is a major binding protein for ______ drugs like _______________.
Major binding protein for ACIDIC drugs like ASA, phenytoin, and VPA
Unbound fraction of drugs
if albumin levels decrease, there is an increase in unbound fraction → exaggerated effect from meds
AAG with aging
May be elevated due to acute illness, cancer, infection, inflammation
AAG has a _______ affinity for ________ drugs.
High affinity for basic drugs
AAG has an affinity for basic drugs. What are some examples of basic drugs?
Amitriptyline, disopyramide, imipramine, lidocaine, nortriptyline, quinidine
