Geriatric PK/PD: Elimination

Question 1

Renal changes with again

Answer 1

Decreased volume and weight
Decreased renal blood flow
Glomerular function
Decreased tubular function

Question 2

What formula do you use to calculate CrCl?

Answer 2

Cockcroft-Gault

Question 3

Renal drug clearance: tubular function

Answer 3

organic base transport doesn’t appear to be altered, organic acid transport appears to decline with age

Question 4

Drugs with a significant renal component to elimination

Answer 4

hydrophilic beta-blockers
ACEIs
Vanco
Gabapentin
AGs

Question 5

Drugs with pharmacologically active metabolites

Answer 5

amoxapine, desipramine, metoprolol, risperidone

Question 6

Active metabolites with detrimental effects

Answer 6

norpropoxyphene (D/C’ed, off market), hydroxyaminodapsone, normeperidine

Question 7

Drug that shunts CL from renal to metabolic pathways

Answer 7

Theophylline