Geriatrics Part II Flashcards

1
Q

Urinary Incontinence

A

involuntary leakage of urine
overactive bladder (most common type of urinary incontinence)

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2
Q

Patients with UI may experience

A

loss of independence: loss of physical, social activity, social isolation
lack of self-esteem: depression, anxiety
additional medical complications

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3
Q

Frequency of UI types in women

A

urge (63%)
stress (21%)

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4
Q

Frequency of UI types in men

A

urge (59%)
overflow (29%)

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5
Q

Normal bladder function

A
  1. stretch receptors notify brain that bladder is full and needs to empty - beta3 receptors support detrusor relaxation/filling
  2. neurologic stimulation initiates contraction - Ach receptors in the dome, alpha-adrenergic receptors in the base and proximal urethra (modulate sphincter muscles around the outlet)
  3. sphincter relaxes allowing release of urine
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6
Q

beta vs cholinergic receptors

A

beta receptors - relaxation
cholinergic receptors - focus on squeezing

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7
Q

Age-related changes to the bladder and urethra

A

decrease bladder capacity/elasticity
increase spontaneous detrusor contractions
decrease sphincter compliance
may result in: incomplete bladder emptying and decrease ability to postpone urination

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8
Q

Types of Incontinence

A

overflow
stress
urge

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9
Q

Overflow

A

urethral blockage
bladder unable to empty properly (inappropriate sphincter relaxation)

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10
Q

Stress

A

relaxed pelvic floor
increased abdominal pressure

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11
Q

Urge

A

bladder oversensitivity from infection
neurologic disorders

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12
Q

Urge urinary incontinence

A

aka: overactive bladder
hyperactivity of detrusor muscle causes sudden & poorly predictable voiding
may cause large or small volume accidents
symptoms include: urgency (unpredictable or unable to control), frequency (excessive feelings of urination)
causes can be neurologic or medications (acetylcholinesterase inhibitors for Alzheimer’s disease)

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13
Q

Prescribing cascade

A

need for more meds in order to treat the side effects experienced from another med

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14
Q

Stress urinary incontinence

A

outlet incompetence (external urethral sphincter) with abdominal pressure
women > men ( due to estrogen deficiency/lifetime experience of childbirth)
most often small volume of accidents
risk factors include: multiple births, estrogen deficiency
can be exacerbated or caused by alpha-antagonists

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15
Q

Stress urinary incontinence symptoms classically associated with

A

laughter
alcohol
caffeine
cough

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16
Q

Overflow incontinence

A

results from outlet obstruction or inability to or uncoordinated detrusor constriction
most commonly from BPH or prostatic blockage of urethra

17
Q

Overflow incontinence symptoms

A

abdominal discomfort or pain
frequency
feeling the need to void shortly after voiding

18
Q

Neurogenic bladder

A

disruption in neurologic innervation of the bladder
inability or uncoordinated detrusor constriction
may also be atony of bladder muscle - stroke, neuropathy (including sever uncontrolled diabetes), spinal cord injury

19
Q

Neurogenic bladder symptoms

A

small urine volume during voiding, small volume accidents
loss of feeling that bladder is full
dribbling of urine
frequency, urgency
increases risks of UTI
increases risks of kidney stones

20
Q

Functional incontinence

A

inability to get to the bathroom in a timely fashion
causes: physical impairment (mobility), change in mental status (dementia), UTI, medications (sedating)

21
Q

Medication causes for incontinence

A

frequency: diuretics, alpha antagonists
urgency: acetylcholinesterase inhibitors
overflow: alpha antagonists, antihistamines

22
Q

UI treatments: non-pharmacological

A

should be provided for all types of urinary incontinence
1. scheduled/timed voiding
2. pelvic floor muscle strengthening (Kegel): 30-60x/day
3. avoiding irritants: coffee, alcohol, caffeine, avoid water before bed
4. absorbent products (pads, shields, adult diapers)
5. catheters

23
Q

UI pharmacologic treatment for overflow

A

alpha-antagonists
injections or surgery

24
Q

UI pharmacologic treatment for stress

A

estrogen
alpha-agonists
SNRI
injections or surgery

25
UI pharmacologic treatment for urge
anticholinergic/antimuscarinic beta3 agonist injections or surgery
26
UI pharmacologic treatment for neurogenic
injections or surgery
27
Goal of pharmacologic treatment for urge UI
reduce detrusor contraction frequency
28
Anticholinergic/antimuscarinic medications
oxybutynin tolterodine solifenacin darifenacin trospium fesoterodine
29
Anticholinergic/antimuscarinic adverse events
dry mouth constipation fatigue confusion tachycardia
30
B3 agonist medications
mirabegron vibegron
31
B3 agonist adverse events
mirabegron: minor increase in BP, UTI vibegron: minor, UTI
32
Max benefit of these meds (for urge UI)
takes at least 4 weeks to achieve taper down over course of 2-4 weeks when stopping med
33
Stress UI management
1. non-pharmacologic management --> kegel 2. duloxetine 40 mg BID, increased sphincter tone to prevent leaks 3. topical estrogen (vaginal atrophy) - estrogen vaginal cream, intravaginal cream inserted via applicator, 21 days on, 7 days off 4. alpha-agonists 5. vaginal pessaries or surgery
34
Overflow UI management
1. address the obstruction 2. alpha-adrenergic blockers (if BPH) - doxazosin, tamsulosin (less hypotension) 3. catheterization
35
Neurogenic UI management
no pharmacologic managment routinely effective - focused on non-pharmacologic management intermittent catherterization botulism A toxin (botox) injections (bladder or urinary sphincter) surgery - augmentation cystoplasty, bladder walls and intestinal walls connected to improve storage capacity
36
Catheters
intermittent straight indwelling condom suprapubic
37
Monitoring
review efficacy after 4-8 weeks monitor consistently for adverse events
38
Pharmacists role in UI
assess for contributing factors educate and support non-pharmacologic management modify dosage forms as needed redognize treatment-related ADR prevent complications, support QOL support deprescribing when appropriate