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Flashcards in GI DISEASES Deck (65)
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61

OCTREOTIDE

SOMATOSTATIN ANALOGUE

-is a LONG ACTING somatostatin analogue

USE:

1) CARCINOID TUMORS: note if tumor is in GIT there are no symptoms noticed at 5-HT is metabolized in the liver 

2) VIPoma

3) ACUTE VARICEAL BLEEDING

4) ACROMEGALY

AE: abdominal cramps, nausea, steatorrhea, gallstones 

62

TREATMENT OF CARCINOID TUMOR

OCTREOTIDE (somatostatin analogue)

63

TREATMENT OF VIPoma (Vasoactive Intestinal Polypeptide)

A non α and β islet cell pancreatic tumor that secretes VIP, produce copious diarrhea.

• Source: PANS in sphincters, gall bladder & small intestine

• Increase water and electrolyte secretion, relax intestinal smooth muscle and sphincters

• Treatment with Somatostatin analog: octreotide

64

TX OF VARICEAL HEMORRHAGE

1) Octreotide: I.V.

A somatostatin derivative with uncertain MOA

Alter portal blood flow and variceal pressure.

Uses: bleeding varices or high risk of repeat bleeding.

Adverse effect: reduce endocrine and exocrine pancreatic activity.

2) NON-SELECTIVE B-BLOCKERS --> Propanolol + Nadolol)

--> are effective in reducing portal pressures

--> β1 & β2 blockade result in ↓CO &↑VC Improves GI blood vessel tone↑systemic vasoconstriction & ↓vasodilation

65

TX OF REYE'S SYNDROME

- Reye’s syndrome is associated with fatty liver, hypoglycemia, and coma – childhood hepatic- encephalopathy.

This is linked to viral infection treated with aspirin.

Therefore, acetaminophen may be advised in place of aspirin.