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Flashcards in GI Drugs Deck (15):
1

H2 blockers, -tidines

reversible block of H2 receptors, decreasing H+ secretion by parietal cells
use: peptic ulcers, gastritis, esophageal reflux
tox:
cimetidine is a P450 inducer, and has anti-androgenic effects, can cross BBB and the placenta causing CNS symptoms, decreases creatinine excretion

2

PPIs, -prazoles

irreversibly inhibit H/K ATPase in stomach parietal cells
use: peptic ulcer, gastritis, esophageal reflux, ZE syndrome, post severe burns (Curling ulcer)
tox: risk of C diff, pneumonia, hip fractures, decreased serum Mg with long term use

3

Bismuth, sucralfate

bind to an ulcer base, providing physical protection and allowing bicarb to establish normal pH gradient
use: allow for ulcer healing, traveler's diarrhea

4

Misoprostol

PGE1 analog, increased production of gastric mucus barrier and decreased acid production
use: prevention of NSAID induced peptic ulcers, kEEEEps PDA open, labor induction
tox: diarrhea, contraindicated in women trying to become preganant

5

Octreotide

long acting somatostatin analog
use: acute variceal bleeding, acromegaly, VIPoma, carcinoid tumors
tox: nausea, cramps, steatorrhea

6

Antacids - General

Can affect absorption, bioavailability, excretion of drugs by alterting pH in gastric lumen or urine
ALL CAN CAUSE HYPOKALEMIA

7

Aluminum Hydroxide

used as an antacid
tox: constipation, hypophosphotemia, proximal muscle weakness, osteodystrophy, seizures

8

Calcium carbonate

used as an antacid
tox: hypercalcemia, rebound acid increase, can chelate other drugs (tetracyclines)

9

Magnesium hydroxide

used as an antacid
tox: diarrhea, hyporeflexia, hypotension, cardiac arrest

10

Name some drugs used as osmotic laxatives?

magnesium hydroxide, magnesium citrate, polyethelene glycol, lactulose

11

Lactulose

osmotic laxative
acidifies the gut lumen, used for hepatic encephalopathy; traps NH3 in the gut as NH4+

12

Infliximab

monoclonal antibody against TNF-alpha
use: Crohn's, UC, RA, ankylosing spondylitis, psoriasis
tox: infection; ALWAYS check for latent TB

13

Sulfasalazine

Combination sulfapyridine (antibacterial) and 5-aminosalicylic acid (anti-inflammatory); activated by colonic bacteria
used in UC and Crohn's
tox: sulfa allergy, oligospermia

14

Ondansetron

5-HT3 antagonist, decreases vagal stimulation
centrally acting anti-emetic
tox: headache, constipation

15

Metoclopramide

D2 receptor antagonist; increases resting tone, contractility, LES tone, motility (no effect on colon)
use: diabetic and post-surgical gastroparesis, antiemetic
tox: parkinsonian effects