GI Pharmacology

Question 1

Give examples of Proton Pump Inhibitors

Answer 1

Omeprazole

Lansoprazole

Question 2

What are PPI’s used for the symptomatic relief of?

Answer 2

Dyspepsia and GORD

Question 3

What do PPI’s prevent and treat?

Answer 3

Peptic Ulcer Disease

Zollinger-Ellison syndrome

Question 4

What is used in H. Pylori eradication therapy?

Answer 4

Omeprazole + Amoxicillin + Clarithromycin (metronidazole if pen allergic)

Question 5

Give an example of a H2 Receptor antagonist

Answer 5

Ranitidine

Question 6

What are H2 Receptor antagonists used for?

Answer 6

Dyspepsia and GORD
Peptic Ulcers
Symptomatic relief of dyspepsia

Question 7

Give examples of Anti-motility drugs

Answer 7

Loperamide

Codeine Phosphate

Question 8

What are anti-motility drugs (loperamide) used to treat?

Answer 8

Acute diarrhoea for symptomatic relief (gastritis, IBS)

Question 9

Give an example of bulk forming laxatives

Answer 9

Ispagula Husk

Question 10

What are bulk forming laxatives used for?

Answer 10

Constipation in faecal impaction
Gastritis caused by viral or bacterial infection
Mild chronic diarrhoea associated with diverticular disease or IBS

Question 11

When might Pancreatin be used?

Answer 11

Reduced pancreatic secretions in CF
After pancreatic tumour removal
Chronic pancreatitis

Question 12

Give examples of Phenothiazines

Answer 12

Procloperazine

Cholorpromazine

Question 13

What are Phenothiazines used for?

Answer 13

Treatment of n/v in wide range of conditions

Question 14

Give examples of anti-emetics (dopamine D2 receptor antagonists)

Answer 14

Metroclopramide

Domperidone

Question 15

What are dopamine D2 receptor antagonists used for?

Answer 15

GORD
Gastroparesis
Treatment of n/v
Domperidone used in drug/chemo induced n/v

Question 16

Give examples of Histamine H1 antagonists

Answer 16

Cyclizine

Cinnarizine

Question 17

What are histamine H1 antagonists used for?

Answer 17

Prevention of n/v in:
Inner ear infection
Vertigo
Motion sickness

Question 18

Give an example of a 5-HT3 receptor antagonist

Answer 18

Odansetron

Question 19

What are 5-HT3 receptor antagonists used for?

Answer 19

Treatment of n/v associated with chemo and radio therapy

IBS - Diarrhoea

Question 20

Give examples of Corticosteroids

Answer 20

Prednisolone

Budesonide

Question 21

When are corticosteroids used?

Answer 21

UC
Hepatitis
Crohn’s

Question 22

Give examples of 5-ASA’s

Answer 22

Mesalazine

Balsalazide

Question 23

What type of drug are 5-ASA’s?

Answer 23

Anti-inflammatory

Question 24

When are 5-ASA’s used?

Answer 24

UC (1st line for mild)

Question 25

Give examples of Mucosal strengthens

Answer 25

Sucralfate | Bismuth Chealate

Question 26

When are mucosal strengthens used?

Answer 26

GORD (prevention of ulcers) | Peptic Ulcers

Question 27

Give examples of Alginates and Antacids

Answer 27

Gaviscon Peptic Mucogel

Question 28

When are alginates and antacids used?

Answer 28

GORD | Dyspepsia

Question 29

Give an example of an anti-muscarinic

Answer 29

Hyoscine butylbromide

Question 30

When are anti-muscarinics used?

Answer 30

Relief of smooth muscle spasm in IBS