GI Viruses Flashcards
(26 cards)
hep fecal oral
A
E
hep blood/sex
B
C
D
HBV leading cause of
chronic hep
cirrhosis
hepatocellular carcinoma
HBV viral proteins
HBc Ag - capsid antigen Hbe Ag - variant HBs Ag - surface antigen (vaccine) HBV DNA polymerase HBx protein
primary cause of hepatic cell destruction
MHC I –> T cell response to peptides from HBcAG and ABeAg
protective HBV Abs
Anti-Hbs
results of acute HBV
most: effective cell-mediated and humoral response –> resolution
next: limited immune response –> chronic
least: fulminant
cause of pre-icteric period
INF-alpha
Sx of pre-icteric period
malaise
anorexia
nausea
RUQ pain
Sx of icteric period
jaundice
dark urine
first indicators of HBV
HBsAg
HBeAg
indication of chronic infection
continued presence of HBsAg > 6 months
absence of anti-HBs
serum markers (resolved)
HBeAg: -
HBsAg: -
Anti-HBc: +
Anti-HBs: +
serum markers (chronic)
HBeAg: +
HBsAg: +
Anti-HBc: +
Anti-HBs: -
serum markers (vaccinated)
HBeAg: -
HBsAg: -
Anti-HBc: -
Anti-HBs: +
asymptomatic carriers (HBV)
presence of HBsAg and anti-HBe
little or no viremia
rare hepatitis or liver damage
minimal chronic carriers (HBV)
higher risk of reactivation
small proportion develop cirrhosis
severe chronic hep (HBV)
more frequent acute symptoms
progressive liver damage
cirrhosis and hepatocellular carcinoma
active HBV immunization
HBsAg
passive immunization
HBIg
HDV infection types
- simultaneous primary coinfection
- chronic coinfection (infants born to infected mom)
- primary D w/ chronic B
polio results
95% - asymptomatic
4% - minor illness (abortive)
1% - major (nonparalytic/paralytic)
nonparalytic poliomyelitis Sx
same as aseptic meningitis
rotavirus mechanism
ingestion infection of epi of jejunum atrophy of villi decrease in digestive enzymes sugars stay in lumen, water follows --> diarrhea
