Sustained proteinuria
> 1-2 g/24hrs
Type of proteinuria in most glomerular diseases in adults
Nonselective
Type of proteinuria in children with MINIMAL CHANGE disease
Selective, composed mainly of albumin
Proteinuria 1-2gm/d Hematuria with rbc cast Pyuria Hypertension Fluid retention Rise in crea with dec in glomerular function
Nephritic syndrome
Rapid rise in crea in nephritic syndrome
The clinical equivalent of the crescentic GN
RPGN
RPGN + lung hemorrhage
Pulmonary - renal syndrome
Proteinuria >3.0 g/d Hypertension Hypercholesterolemia Hypoalbuminemia Edema/anasarca Microscopic hematuria
Nephrotic syndrome
ANCA-positive
Pauci-immune glomerulonephritis
Granulomatous polyangiitis
Microscopic polyangiitis
Churg-Strauss syndrome
Tram tracking
Type I membranoproliferative GN
No obvious glomerular lesion by LM negative for deposits by IF
Effacement of foot processes by Em
Minimal change (nil) disease
Adequate renal biopsy sample
At least 10, ideally 20 glomeruli
Descriptions of renal biopsy specimen
Diffuse >50% of glomeruli
Focal < 50%
Segmental
Global
Most common Nephrotic sydrome in elderly
30% in adults
Uniform thickening of basement membrane by LM
Diffuse granular deposits of IgG and C3
Highest reported incidence of renal vein thrombosis, pulmonary embo, DVT
Membranous GN
