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Unit 6: Path - Bones and Joints > Gout > Flashcards

Flashcards in Gout Deck (15)
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1
Q

What is primary gout caused by?

A

Disorder of Uric acid metabolism

2
Q

Four factors leading to gout?

A
  1. Overproduction of purines
  2. Increased catabolism of nuclei acids due to greater cell turnover
  3. Decreased salvage of free purine bases
  4. Decreased urinary uric acid excretion
3
Q

What are most cases of idiopathic gout explained by?

A

Impairment of renal uric acid exccretion

4
Q

What X-linked disease is associated with gout?

A

Lesch-Nylan Syndrome

5
Q

What is the deficiency resulting in the hyperuricemia found in Lesch-Nylan Syndrome?

A

Deficiency of Hypoxanthine Phosphoribosyl Transferase (HPRT)

6
Q

What does Seconday Gout typically result from?

A

DNA turnover

7
Q

What is the condition in which lead nephropathy leads to gout?

A

Saturine gout

8
Q

What are the crystals that deposit in the body of a person with gout?

A

Sodium urate

9
Q

How is gout Dx?

A

Presence of long, needle-shaped crystals that are negatively birefringent under polarized light

10
Q

What is extracellular soft tissue deposit of urate crystals surrounded by foreign body giant cells and an associated inflammatory response of mononuclear cells?

A

Tophus

11
Q

What are radiologic findings in gout?

A

Punched-out juxta-articular, lytic (“rat-bite”) lesions that are associated with only minimal reactive new bone

12
Q

Clinical course of gout?

A
  1. ASyx hyperuricemia
  2. Acute gouty arthritis
  3. Intercritical gout
  4. Chronic gouty tophus
13
Q

Painful red first metatarsophalangeal joint commonly found in gout?

A

Podagra

14
Q

Inciting factors of gouty attack?

A

Alcohol, large proteinaceous meal

15
Q

What is tophaceous gout?

A

Form of tophi in the cartilage, synovial membranes, tendons, soft tissues