What is primary gout caused by?
Disorder of Uric acid metabolism
Four factors leading to gout?
- Overproduction of purines
- Increased catabolism of nuclei acids due to greater cell turnover
- Decreased salvage of free purine bases
- Decreased urinary uric acid excretion
What are most cases of idiopathic gout explained by?
Impairment of renal uric acid exccretion
What X-linked disease is associated with gout?
What is the deficiency resulting in the hyperuricemia found in Lesch-Nylan Syndrome?
Deficiency of Hypoxanthine Phosphoribosyl Transferase (HPRT)
What does Seconday Gout typically result from?
What is the condition in which lead nephropathy leads to gout?
What are the crystals that deposit in the body of a person with gout?
How is gout Dx?
Presence of long, needle-shaped crystals that are negatively birefringent under polarized light
What is extracellular soft tissue deposit of urate crystals surrounded by foreign body giant cells and an associated inflammatory response of mononuclear cells?
What are radiologic findings in gout?
Punched-out juxta-articular, lytic ("rat-bite") lesions that are associated with only minimal reactive new bone
Clinical course of gout?
- ASyx hyperuricemia
- Acute gouty arthritis
- Intercritical gout
- Chronic gouty tophus
Painful red first metatarsophalangeal joint commonly found in gout?
Inciting factors of gouty attack?
Alcohol, large proteinaceous meal
What is tophaceous gout?
Form of tophi in the cartilage, synovial membranes, tendons, soft tissues