Gout Flashcards Preview

Unit 6: Path - Bones and Joints > Gout > Flashcards

Flashcards in Gout Deck (15):
1


What is primary gout caused by?


Disorder of Uric acid metabolism

2


Four factors leading to gout?

 

  1. Overproduction of purines
  2. Increased catabolism of nuclei acids due to greater cell turnover
  3. Decreased salvage of free purine bases
  4. Decreased urinary uric acid excretion

3


What are most cases of idiopathic gout explained by?


Impairment of renal uric acid exccretion

4


What X-linked disease is associated with gout?


Lesch-Nylan Syndrome

5


What is the deficiency resulting in the hyperuricemia found in Lesch-Nylan Syndrome?


Deficiency of Hypoxanthine Phosphoribosyl Transferase (HPRT)

6


What does Seconday Gout typically result from?


DNA turnover

7


What is the condition in which lead nephropathy leads to gout?


Saturine gout

8


What are the crystals that deposit in the body of a person with gout?


Sodium urate

9


How is gout Dx?


Presence of long, needle-shaped crystals that are negatively birefringent under polarized light

10


What is extracellular soft tissue deposit of urate crystals surrounded by foreign body giant cells and an associated inflammatory response of mononuclear cells?


Tophus

11


What are radiologic findings in gout?


Punched-out juxta-articular, lytic ("rat-bite") lesions that are associated with only minimal reactive new bone

12


Clinical course of gout?

 

  1. ASyx hyperuricemia
  2. Acute gouty arthritis
  3. Intercritical gout
  4. Chronic gouty tophus

13


Painful red first metatarsophalangeal joint commonly found in gout?


Podagra

14


Inciting factors of gouty attack?


Alcohol, large proteinaceous meal

15


What is tophaceous gout?


Form of tophi in the cartilage, synovial membranes, tendons, soft tissues