Gout Flashcards
1
Q
gout mechanism of action
A
crystallization of uric acid in blood which usually gravitates towards lower dependent joints, causing erythema and pain
2
Q
gout meds
A
allopurinol
colchicine
(glucocorticoid, NSAIDs for minor attacks)
3
Q
allopurinol mechanism of action
A
blocks enzymes converting uric acid, allowing excretion of hypoxanthine which does not crystallize
4
Q
allopurinol use
A
prevention and tx
full effect in 1-2mo
effective if uric acid <6mg/mL
indicated for certain cancers
5
Q
issues w/allopurinol
A
acute gout attack
hypersensitivity, hepatotoxicity (rare)
avoid: amoxicillin (hypersensitivity)
6
Q
issues w/colchicine
A
prevention and tx gout
diarrhea (common)
myopathy
bone marrow supression
