gp2

Question 1

red flags for cough

Answer 1

night sweats, unexplained weightloss, prolonged cough

Question 2

massive baby in utero is called

Answer 2

macrosomia

Question 3

how would you discover disproportionate short stature

Answer 3

do sub ischial standard deviation - sitting standard deviation

Question 4

which gene leri weill

Answer 4

SHOX

Question 5

which bones leri weill

Answer 5

radius/ulna
tibia/fibula

Question 6

where is shox gene situation

Answer 6

on both X and Y

Question 7

what is this defformity

Answer 7

Madelung (short stature) deformity don’t fit properly together

Question 8

causes of disproportionate short stature (4)

Answer 8

achondroplasia
hypochondroplasia
ricketts
Leri Weill dyschondrosteosis

Question 9

when are most girls with Turner diagnosed

Answer 9

adulthood

Question 10

all girls with short stature need a…

Answer 10

karyotype analysis

Question 11

GH is secreted in what style

Answer 11

pulsatile

Question 12

GH biggest peak

Answer 12

deep sleep

Question 13

GH deficiency characterised by

Answer 13

decrease of velocity (plateauing) of growth

Question 14

GH deficiency length at birth

Answer 14

normal or only slightly reduced

Question 15

do you use oxandrolone for GH deficiency? what is it

Answer 15

no. anabolic steroid

Question 16

growing tx for Turner’s

Answer 16

oxandrolone

Question 17

definition of delayed puberty

Answer 17

have not reached Tanner stage 2 by 13 in girls and 14 in boys

Question 18

what drug to block puberty

Answer 18

GNRH - desensitising

Question 19

from which stage is puberty irreversible

Answer 19

Tanner stage 3

Question 20

risk allele for alzheimers

Answer 20

ApoE4

Question 21

what is Laron syndrome

Answer 21

GH signalling broken, tiny patients who don’t age

Question 22

what is mTor pathway

Answer 22

anabolic pathway to produce protein

Question 23

which hormones are released by muscle to stimulate brain neurogenesis

Answer 23

irisin, cathepsin beta

Question 24

metformin blunts what physiological advantage

Answer 24

muscle hypertrophy and mitochondrial advantages

Question 25

mediator of broken heart syndrome

Answer 25

cortisol

Question 26

what sort of drug currently in clinical trials can wipe out senescent cells

Answer 26

senolytics