viruses and vaccinations Flashcards

(32 cards)

1
Q

which specific ig can be injected for passive immunity

A

gamma globulin

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1
Q

fever definition

A

> 37.8

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2
Q

which cell is the only cell which can ctivate naive T cell

A

dendritic cell

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3
Q

where do most memory T cells live

A

tissue

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4
Q

what increases immunogenicity of vaccines that contain inactivated antigens

A

vaccine adjuvant

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5
Q

who can’t have attenuated vaccine

A

immunosuppressed- danger of infectino

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6
Q

only viral vector vaccine

A

ebola

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7
Q

what pathogens cause meningitis at different ages

A
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8
Q

which vaccine type provides best protection

A

live attenuated

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9
Q

which ig is released first

A

IgM

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10
Q

which antibody can only be

A
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11
Q

childhood immunity schedule

A

Diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type b and hepatitis B
8 weeks
12 weeks
16 weeks
Diphtheria, tetanus, pertussis and polio
3 years 4 months
Tetanus, diphtheria and polio
14 years

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12
Q

what are infants very bad at mounting immune response against and what is the solution

A

polysaccharides - conjugate with a peptide

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13
Q

what does rotavirus vaccine protect against specifically

A

serious disease

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14
Q

what is interesting about measles vax

A

can be administered after infection to help recovery

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15
Q

calculation for herd immunity

16
Q

what does R0 mean

A

basic reproduction number of a disease

17
Q

cholera and diphtheria and C diff produce

18
Q

what is this illlness and what can you see

A

diphtheria, pseudomembrane

19
Q

how does diphtheria toxin works

A

inhibits protein synthessi

20
Q

cytokines implicated in sepsis at he beginning

A

IL-6, TNF-alpha

21
Q

eustachian tube in infant is..

A

more horizontally orientated

22
Q

which chemo med for sickle cell, how does it help

A

Hydroxycarbamide/hydroxyurea (same thing), increases HbF

23
Q

who is predisposed to pneumococcal infection and what do you give them

A

Absent / non-functional spleen
Congenital asplenia
Traumatic removal
Hyposplenism (eg sickle cell)
Hypogammaglobulinaemia
HIV infection

give PPV pneumococcal Polysaccharide vaccine

24
why treat otitis media promptly
can spread to meninges
25
what is empyema
pus-filled pockets that develop in the pleural space.
26
which children susceptible to mould/yeast sepsis
very premature or under tx for leukaemia
27
which causes worst form of malaria and what is the proble
P. falciparum - cerebral malaria
28
severe malaria in children symptoms (4)
Anaemia Respiratory distress Cerebral malaria (coma, seizures) Hypoglycaemia
29
tx for congenital CMV - how does it work
IV ganciclovir or oral valganciclovir (pro-drug) – inhibits DNA synthesis
30
Epstein-Barr associated with what malignancy esp in Africa
Burkitt's Lymphoma
31