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Year 2 HD > viruses and vaccinations > Flashcards

viruses and vaccinations Flashcards

1
Q

which specific ig can be injected for passive immunity

A

gamma globulin

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1
Q

fever definition

A

> 37.8

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2
Q

which cell is the only cell which can ctivate naive T cell

A

dendritic cell

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3
Q

where do most memory T cells live

A

tissue

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4
Q

what increases immunogenicity of vaccines that contain inactivated antigens

A

vaccine adjuvant

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5
Q

who can’t have attenuated vaccine

A

immunosuppressed- danger of infectino

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6
Q

only viral vector vaccine

A

ebola

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7
Q

what pathogens cause meningitis at different ages

A
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8
Q

which vaccine type provides best protection

A

live attenuated

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9
Q

which ig is released first

A

IgM

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10
Q

which antibody can only be

A
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11
Q

childhood immunity schedule

A

Diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type b and hepatitis B
8 weeks
12 weeks
16 weeks
Diphtheria, tetanus, pertussis and polio
3 years 4 months
Tetanus, diphtheria and polio
14 years

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12
Q

what are infants very bad at mounting immune response against and what is the solution

A

polysaccharides - conjugate with a peptide

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13
Q

what does rotavirus vaccine protect against specifically

A

serious disease

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14
Q

what is interesting about measles vax

A

can be administered after infection to help recovery

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15
Q

calculation for herd immunity

A

1-1/R0

16
Q

what does R0 mean

A

basic reproduction number of a disease

17
Q

cholera and diphtheria and C diff produce

A

exotoxins

18
Q

what is this illlness and what can you see

A

diphtheria, pseudomembrane

19
Q

how does diphtheria toxin works

A

inhibits protein synthessi

20
Q

cytokines implicated in sepsis at he beginning

A

IL-6, TNF-alpha

21
Q

eustachian tube in infant is..

A

more horizontally orientated

22
Q

which chemo med for sickle cell, how does it help

A

Hydroxycarbamide/hydroxyurea (same thing), increases HbF

23
Q

who is predisposed to pneumococcal infection and what do you give them

A

Absent / non-functional spleen
Congenital asplenia
Traumatic removal
Hyposplenism (eg sickle cell)
Hypogammaglobulinaemia
HIV infection

give PPV pneumococcal Polysaccharide vaccine

24
Q

why treat otitis media promptly

A

can spread to meninges

25
Q

what is empyema

A

pus-filled pockets that develop in the pleural space.

26
Q

which children susceptible to mould/yeast sepsis

A

very premature or under tx for leukaemia

27
Q

which causes worst form of malaria and what is the proble

A

P. falciparum - cerebral malaria

28
Q

severe malaria in children symptoms (4)

A

Anaemia
Respiratory distress
Cerebral malaria (coma, seizures)
Hypoglycaemia

29
Q

tx for congenital CMV - how does it work

A

IV ganciclovir or oral valganciclovir (pro-drug) – inhibits DNA synthesis

30
Q

Epstein-Barr associated with what malignancy esp in Africa

A

Burkitt’s Lymphoma

31
Q
A

Year 2 HD (15 decks)

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