Granules

Question 1

Agglomerates of powdered materials (range of 4-12 sieve sizes)

Answer 1

GRANULES

Question 2

Granulations of powders used in tablet making and other pharmaceutical purposes

Answer 2

GRANULES

Question 3

Irregularly shaped but maybe spherical

Answer 3

GRANULES

Question 4

Provide a pleasant vehicle for selected drugs with bitter and salty taste.

Answer 4

GRANULES

Question 5

Method of preparation for granules:

Answer 5

Wet Granulation
Dry Granulation

Question 6

What are the two methods for wet granulation?

Answer 6

Basic wet method
Fluid Bed processing

Question 7

Moisten the powder/ powder mixture → pass the paste through a screen of mesh size→ placed in
a drying trays & dried by air under heat (oven drying) →granules

Answer 7

Basic wet method

Question 8

why are *Granules are place in the drying trays

Answer 8

to prevent adhesion into large mass*

Question 9

Forms granules or pellets

Answer 9

Fluid bed processing

Question 10

Particles in conical piece of equipment dispersed and suspended

Answer 10

Fluid bed processing

Question 11

Liquid excipients were sprayed & dried → granules/ pellets were formed in desired particle size

Answer 11

Fluid bed processing

Question 12

Dry method or “FUSION METHOD”

Answer 12

Dry Granulation

Question 13

Another name for dry method

Answer 13

Fusion method

Question 14

A dry powder is passed through a roll compactor (rotating metal roll) and then through a granulating machine

Answer 14

Dry Granulation

Question 15

Use of roll press or roller compactor & a granulating machine

Answer 15

Dry Granulation

Question 16

also called a roll press or roller compactor

Answer 16

Dry Granulation

Question 17

Processes a fine powder into dense sheets or forms

Answer 17

Roll compactor-

Question 18

compression of a powder or powder mixture under 8000-1200 pounds of pressure

Answer 18

Slugging

Question 19

flat faced and about 2.5cm (1in) in diameter

Answer 19

SLUGS

Question 20

Characteristics of Granules:
 Flow well/ free flowing
 Granules flow well compared to powders
 Granulation are commonly used in tablet making to facilitate the free flow
 More stable to atmospheric humidity
 Less likely to cake or harden upon standing
 Compressibility
 Easily wetted by liquid
 Has better dissolution than powders

Question 21

What arethe micromeritics that affects Particle size can influence a variety of important factors:

Answer 21

Dissolution
Suspendability
Uniform distribution
Penetrability
Lack of gritiness

Question 22

science of small particles

Answer 22

Micromeritics-

Question 23

(rate of particles intended to dissolve)

Answer 23

Dissolution

Question 24

increase in drug dissolution & bioavailability

Answer 24

decrease in particle size

Question 25

(intended to remain undissolved but uniformly dispersed in big vehicle)

Answer 25

Suspendability

Question 26

ensure dose to dose content uniformity

Answer 26

Uniform distribution

Question 27

intended to be inhaled for deposition deep in respiratory tract

Answer 27

Penetrability of particles

Question 28

solid particles in dermal ointments, creams & ophthalmic preparations

Answer 28

Lack of grittiness