GU pharm chart Flashcards
(117 cards)
1
Q
what are the two PDE5 inhibitors
A
Sildenafil
Tadalafil
2
Q
what is the PDE5 inhibitors MOA
A
inhibits PDE5 to incr [NO] leading to corpus cavernosum relaxation & inflow of blood to cause erection
3
Q
what is the indication of the PED5 inhibitors
A
ED
Pulm artery hypertension [Adcirca]/ [Revatio]
4
Q
what is the 5α-reductase inhibitor
A
Finasteride
5
Q
what is the MOA of Finasteride
A
decreases prostatic tissue growth sec to inhibiting conversion testosterone to dihydrotestosterone
reduce static factor & induce apoptosis glandular cells;
6
Q
what is the indicaiton of Finasteride
A
2nd line for Mod to Severe BPH (AUA scores)
7
Q
what is the α1 adrenergic antagonist
3rd Generation
A
Tamulosin
8
Q
MOA of Tamulosin
A
relax bladder neck, prostatic urethra, prostatic sm muscle
9
Q
indication of Tamulosin
A
Mod to Severe BPH (AUA scores)
reduce dynamic factor (neurologic inhibition)
10
Q
what is the herbal drug currently not recommended
A
Saw Palmetto
11
Q
what are the Anti-androgen
Anti-neoplastic
A
Leuprolide
Flutamide
12
Q
what si the MOA of Leuprolide
A
GnRH agonist;
agonist of LHRH
13
Q
what is the indications of Leuprolide
A
palliative Rx prostate cancer;
endometriosis
14
Q
MOA of Flutamide
A
nonsteroidal anti-androgen that inhibits androgen binding in target tissues
15
Q
indications of Flutamide
A
metastatic prostate cancer w/ LHRH agonist
16
Q
what is a sex hormone androgen drug
A
testosterone
17
Q
what is the MOA of testosterone
A
replacement
18
Q
what is the indication of testosterone
A
hypogonadism
19
Q
what are the two M3 antimuscarinic
A
Oxybutinin
Tolterodine
20
Q
MOA of M3 antimuscarinic
A
selective antagonist of bladder muscarinic receptors decr detrussor muscle pressure, incr residual urine volume
21
Q
indication of M3 antimuscarinic
A
overactive bladder,
urge incontinence
22
Q
what is the Beta-3 Agnoist
A
Mirabegron
23
Q
MOA of Mirabegron
A
activates beta-3 adrenergic receptors in bladder relaxing detrussor muscle during urine storage phase
24
Q
indication of Mirabegron
A
Overactive bladder w/ sxs of urinary frequency, urgency, or urge UI
25
what is the Tricyclic
| Antidepressant
Imipramine
26
MOA of Imipramine
incr synaptic [serotonin, norepinephrine]; down regulation of ß-andrenergic receptors; anti-cholinergic effect
27
indication of Imipramine
depression;
off label for anticholinergic impact in UI
28
Anti-hypertensive:
Central alpha-adrenergic inhibitor
Alpha2-adrenergic agonist
Methyldopa
29
MOA of Methyldopa
central alpha-adrenergic inhibition decrease sym outflow to heart, kidneys, peripheral vasculature
30
indications of Methyldopa
HTN in PG
31
Anti-hypertensive:
Non-selective Alpha1 & Beta Receptor Blocker
Beta blocker w/alpha activity
Labetalol
32
MOA of Labetalol
Blocks α-, β1-, β2-adrenergic receptors
33
Indications of Labetalol
HTN in PG
34
Folic Acid is in what drug class
Vitamin
| Water Soluble
35
MOA of Folic Acid
Folate required for formation of multiple co-enzymes in protein synthesis
36
indications of Folic Acid
supplement to prevent neural tube defects
37
Vitamin B6
| Anti-Nauseant w/ Doxylamine
Pyridoxine
38
MOA of Pyridoxine
With Doxylamine use:
| inhibits CRTZ; diminishes vestibular stimulation; depresses labyrinthine function; sedating
39
indications of Pyridoxine
N/V of pregnancy
40
Antihistamine
| Anti-Nauseant w/ Pyridoxine
Doxylamine
Don’t confuse w/ Doxycycline abx
41
MOA of Doxylamine
With Doxylamine use:
| inhibits CRTZ; diminishes vestibular stimulation; depresses labyrinthine function; sedating
42
Indications fo Doxylamine
N/V of pregnancy
43
Other alternatives for N/V
metaclopromide, diphenhydramine
44
Tocolytic Agents
Magnesium Sulfate
45
MOA of
| Magnesium Sulfate
decr acetylcholine in motor nerve terminals;
| slows rate S-A node impulse formation; relaxation of bronchial smooth muscle
46
Indications of
| Magnesium Sulfate
```
premature labor/eclampsia;
seizure;
torsade de pointes;
severe Mg deficiency;
unresponsive status asthmaticus (in children)
```
47
Antiretroviral agent
| RTI (nucleoside & nucleotide)
Tenofovir/ Emtricitabine
48
MOA of Tenofovir/ Emtricitabine
each interferes with DNA polymerase function resulting in viral inhibition
49
indications of Tenofovir/ Emtricitabine
HIV1, PrEP;
Unlabeled: Hep B (in patients w/ antiviral resistant ds or co-infection w/ HIV)
50
Miscellaneous PG Meds:
| Opioids
o Codeine, hydrocodone, oxycodone, meperidine
o Heart defects – studies retrospective, case-control so ? causation?
o Pain treatment: APAP drug of choice (avoid NSAIDS)
51
Miscellaneous PG Meds: Antipsychotics
o Potential risk of extrapyramidal signs & withdrawal symptoms in neonate
52
Miscellaneous PG Meds:
| Anti-depressants
o Paxil – Cat D (other SSRI’s are PG Cat C)
| o Fluoxetine
53
Miscellaneous PG Meds:
| Anti-seizure drugs
o Topiramate, phenytoin, carbamazepine, valproate – all PG Cat D
54
Combo Oral Contraceptive:
Monophasic
Loestrin Fe 1/20
| norethindrone acetate, ethinyl estradiol
55
MOA of all COMBO ORAL CONTRACEPTIVES
suppression of FSH, LH with suppression of ovulation (~90%) & reduced implantation (~10%);
thickening cervical mucus, decr tubal motility
56
Indications of Loestrin Fe 1/20
Contraception, etc
57
Combo Oral Contraceptive:
| Biphasic
Lo Loestrin Fe
norethindrone acetate 1mg/ ethinyl estradiol 10, 10 mcg
58
indications of Lo Loestrin Fe
Contraception, etc
59
Combo Oral Contraceptive:
| Triphasic
Triphasil
levonorgestrel / ethinyl estradiol 0.05mg/30mcg, 0.075mg/40mcg, 0.125mg/30mcg
60
indications of Triphasil
Contraception, etc
Peri-menopause
61
Combo Oral Contraceptive(OC):
| Quadriphasic
Natazia
| Dionogest/ Estradiol valerate 0mg/3mcg, 2mg/2mcg, 3mg/1mcg; 0mg/1mcg
62
indications of Natazia
Contraception, etc
Peri-menopause
63
Progestin-only OC
Ovrette
norgestrel 0.075mg
64
MOA of Ovrette
prevent mid-cycle FSH/LH surge,
inhibit ovulation (less than COC) & implantation,
thicken cervical mucus, slow tubal transport
65
indications of Ovrette
contraception; contraception in women where COC is C/I
66
Extended Cycle OC
Lybrel
levonorgestrel / EE 0.09mg/ 0.02mg
67
MOA of Lybrel
prevent mid-cycle FSH/LH surge,
inhibit ovulation & implantation,
thicken cervical mucus, slow tubal transport
68
indications of Lybrel
contraception; women w/ menstral related sxs: (HA, menorrhagia, anemia, endometriosis-related pain)
69
Ascending Dose Extended Cycle OC
Quartette
| Levonorgestrel/ EE 0.15mg/0.02mg (42 days);
0.15mg/ 0.025mg (21 days); 0.15mg/0.03mg (21 days);
EE 0.01mg
(7 days
70
MOA of Quartette
prevent mid-cycle FSH/LH surge,
inhibit ovulation & implantation,
thicken cervical mucus, slow tubal transport
71
indications of Quartette
contraception; women w/ menstral related symptoms (HA, menorrhagia, anemia, endometriosis-related pain)
72
what is the drug class of Ethinyl Estradiol and Conjugated Equine Estrogen CEE
Estrogen
73
MOA of estrogen drugs
Estrogen supplement
74
indications of estrogen drugs
Moderate to severe vasomotor symptoms
Vaginal mucosal atrophy
Hypogonadism
75
Depo MPA is what drug class
Progestogen
76
MOA of MPA
prevent mid-cycle FSH/LH surge,
inhibit ovulation (less than COC) & implantation,
thicken cervical mucus, slow tubal transport
77
indications of MPA
contraception; esp woman who have contra- for EE
78
what are the two names of the IUD's
Levonorgestre 1 IUD (mirena)
| Copper IUD
79
indications of Levonorgestrel IUD
contraception for 5 years
80
indications of Copper IUD
contraception for 10 years
81
```
which drug is under the class Mixed 5-HT1AAgonist/
5-HT2A Antagonist
```
Flibanserin
82
MOA of Flibanserin
Not known although is known to be an agonist at 5-HT1A and antagonist at 5-HT2A receptors;
moderate activity at other CNS receptors (5-HT2B and 5-HT2C, D4)
83
indications of Flibanserin
Acquired, generalized hypoactive sexual desire disorder in premenopause females
84
which drug is under the class: Selective Estrogen Receptor Modulator (SERM)
estrogen agonist/antagonist
Ospemifene
85
MOA of Ospemifene
selective activation/inhibition of estrogen pathways in different tissues;
agonistic effects on endometrium
86
indications of Ospemifene
Mod to severe dyspareunia due to vulvar and vaginal atrophy in postmenopausal females
87
which drug is in the class: Abortifactant
Mifepristone
88
MOA of Mifepristone
Inhibits progesterone receptors, antagonizing endometrial & myometrial effects
89
indications of Mifepristone
Early Pregnancy Termination
90
which drug is in the class: Post Exposure Contraception
Ulipristal
| [Ella]
91
MOA of Ulipristal
| [Ella]
progesterone agonist-antagonist
92
Indications of Ulipristal
| [Ella]
Post Exposure Contraception
93
what are the five ABX?
```
Metrionidazole
Ceftriaxone
Azithromyocin
Benzathine Penicillin C
Doxycycline
```
94
MOA of Metrionidazole
Inhibits protein synthesis in susceptible organisms when chemical structure is reduced
95
indications of Metrionidazole
Trichomoniasis Bacterial Vaginosis
DOC for anaerobes in intra-abdominal infection. C.diff, Giardiasis, Amebiasis.
96
MOA of Ceftriaxone
In actively growing bacterial cells, interferes w/ transpeptidation of bacterial cell walls by binding to penicillin binding protein (PBP)
97
Indications of Ceftriaxone
Gonorrhea
Gram+, more Gram-
coverage; Acute OM, Sinusitis, LRTI, Meningitis; Empiric Rx of serious infections pending C&S
98
MOA of Azithromyocin
Reversibly bind to 50S subunit of bacterial ribosome & inhibit protein synthesis
99
Indications of Azithromyocin
Chlamydia
Penicillin substitute Atypical pneumonia, CAP, PID, Acute OM, Sinusitis, Pharyngitis, COPD, Pertussis
100
Indications of Benzathine Penicillin C
Syphilis
101
MOA of Doxycycline
Inteferes with bacterial 30S ribosome protein production
102
Indications of Doxycycline
Syphilis
CAP, Sinusitis, Lyme, Plague ricketssiae, rosacea, periodontitis, cholera
103
```
what drug is in the class: Anti-
RETROviral RTI (nucleoside), RTI (nucleotide)
```
Tenofovir/Emtricitabine
104
MOA of Tenofovir/Emtricitabine
Inteferes w/DNA polymerase function resulting in viral inhibition
105
Indications of Tenofovir/Emtricitabine
HIV1, PrEp
Unlabeled: Hep B (in pts. w/antiviral resistant dz or co-
infection w/HIV)
106
what is the drug in this class: anti-viral
Valcyclovir
107
MOA of Valcyclovir
Inhibits DNA polymerase; incorporates into viral DNA
108
Indications of Valcyclovir
HSV, Herpes Zoster (shingles)
109
what is the drug in the class: anti-fungal
Clotrimazole Cream
110
MOA of Clotrimazole Cream
Alters fungal cell well permeability, and jacks up fungi in other ways.
111
Indications of Clotrimazole Cream
Candidiasis (vulvovaginal or breast)
Fungal infections, incl. vulvovaginal candidiasis (yeast
infection)
112
what drug is in the class Antibacterial?
Nitrofurantoin
113
MOA of Nitrofurantoin
inhibits several bacterial enzyme systems including acetyl coenzyme A interfering with metabolism and possibly cell wall synthesis
114
Indications of Nitrofurantoin
UTIs d/t susceptible E. coli, S. aureus, Enterococcus, Klebsiella, and Enterobacter
115
What class is Ibuprofen in?
NSAIDS
116
MOA of Ibuprofen
Analgesic and antipyretic effects through inhibition of prostaglandin synthesis
117
Indications of Ibuprofen
Pain, fever, HA, dysmenorrhea, rheumatoid arthritis
