Gynae Flashcards
(29 cards)
Most important factor in cause of OHSS
VEGF-A
Most common gynae cancer
Endometrial cancer
Name estrogen secreting ovarian tumors
Granulosa cell tumors
Uterine thickness in MM for ruling out endometrial cancer
4mm
What blood tests for granulosa cell tumors
Inhibin and eastradiol
First line treatment for endometrial hyperplasia without atypia
Medical (usually), pref. LNG-IUS
First line treatment for endometrial hyperplasia with atypia
Hysterectomy +/- bilateral salpingo-oophrectomy
When does GTD become GTN
If hCG remains raised after primary treatment of GTD it becomes GTN
Does molar pregnancy require anti D
Complete molar no
Partial molar yes
OHSS blood results
Elevated heamatocrit
Reduced serum osmolality
Low sodium
Key features of granulosa cell tumors
Most common, esp in middle aged women
Have call-exner bodies - disarrayed granulose cells surrounded by small eosinophilic fluid filled spaces
Produce TONS of estrogen
Fibroma tumors?
Benign, from fibroblast cells
Associated with ascites
Needle like strands (long nuclei) on histology
Meigs syndrome?
Benign tumor, ascites, pleural effusion
(Fibroma)
Seroli-leydig tumors?
Look like the cells found in men
Produce testosterone (leading to hirsutism)
Reinke crystals(pink rod like crystals in cell cytoplasm) under microscope
What gynae conditions carry increased risk for ovarian cancer
Endometriosis
PCOS
What is a sister Mary Joseph nodule
(Ovarian (maybe)( cancer metastasis to the umbilicus
Who is most at risk of epithelial cell ovarian tumors
Post menopausal, BRCA 1, lynch syndrome
Histological feature of malignant ovarian epithelial tumours
Papillary projections (shaggy appearance)
What histologic association is there with serous cystadenomas
Psammoma bodies
What are psammoma bodies described as
Dystrophic calcifications
Calcific spherules, layered
Brenner cyst?
Cyst lined with transitional bladder epithelium
Dysgerminoma features
Premenopausal
“Fried egg” histology (large cells with clear cytoplasm and large nucleii)
Dysgerminoma tumor markers
PLAP, bhcG, LDH
Yolk sac tumor features
Young, usually child
Schiller-duval bodies (endodermal sinuses) resemble primitive glomeruli
