Haematological Agents Flashcards
(19 cards)
Agents acting on erythropoiesis
Darbapoetin alpha
Agents acting on leucopoesis
Filgrastim
Erythropoietin
Main Erythropoiesis regulating hormone produced in kidney,
Endogenous Erythropoietin production is impaired in patients with
Chronic kidney disease
What are the necessary components for Erythropoiesis
Iron,vit B 12, folic acid
Erythropoietin analogue ( Darbapoetin Alfa) is
Glycolyzed r- HuEPO( recombinant human EPO amino acid identical to endogenous Erythropoietin
Erythropoietin analogue ( Darbapoetin alfa) action
Erythropoietin receptor agonist in the bone marrow erythrocyte progenitor cells, erythropoiesis stimulating effect ,anti anemia effect
Clinical use of Darbapoetin Alfa( erythropoietin analogue
Chronic kidney disease induced or renal anemia, Tumour chemotherapy induced anemia
Side effects of Darbapoetin Alfa! Erythropoietin analogue)
Hypertension, hypersensitivity reaction s
Fe 2+ drugs
Iron sulphate and iron fumarate
Fe3+ drugs
Iron isomaltose
Iron drugs action
Affect Erythropoiesis ( heam formation) in the bone marrow
Side effects of iron drugs
GI irritation, allergic reactions, hemosiderosis
use of iron drugs
Iron deficiency anemia
50 percent of oncology patients have
Anemia
G- CSF ( granulocyte colony stimulating factor) analogue)- Filgrastim action
G- CSF receptor agonist in bone marrow ( promote proliferation of neutrophil and stimutes their release from bone marrow
Leucopoesis stimulating effect
G- CSF analogue - filgrastim use
Cytotoxic chemotherapy induced granulocytopenia,neutropenia
GCSF significantly reduced the incidence of
Infectious complications of cytotoxic drugs
Side effects of G- CSF analogue - Filgrastim
Arthralgia,myalgia
