Haematology disorders - Red cell and Clotting disorders

Question 1

Anemia

S/S

Answer 1

Question 2

Red cell indices

Answer 2

Question 3

Use of WBC and PLT count in anemia

Answer 3

Question 4

Peripheral blood smear

Types of abnormal RBC

Answer 4

Question 5

Ddx normocytic anemia
Howell Jolly bodies
Polychromasia
Basophilic stippling

Answer 5

Question 6

Ddx target cells
Spherocytes
Red cell fragments

Answer 6

Question 7

Ddx low RBC production

Answer 7

Question 8

Ddx increased peripheral consumption of RBC

Answer 8

Question 9

Ddx normocytic, microcytic, macrocytic anemia

Answer 9

Question 10

Approach to microcytic anemia

Answer 10

Question 11

Approach to macrocytic anemia

Answer 11

Question 12

Microcytic anemia

Ddx

Answer 12

Question 13

Mc Anemia

Ix

Answer 13

Question 14

Iron metabolism

Absorption
Recycling
Storage

Answer 14

Question 15

Iron deficiency

Causes

Answer 15

Question 16

Progression of iron deficiency

Answer 16

Question 17

IDA

S/S

Answer 17

Question 18

IDA

Ix

Answer 18

Question 19

IDA

Mx
Causes of refractory IDA

Answer 19

Question 20

Thalassemia

Pathogenesis

Answer 20

Question 21

A-thal

Pathogenesis

Answer 21

Question 22

A thal

Clinical presentation in minima, minor, intermedia, major

Answer 22

Question 23

B-thal

Pathogenesis

Answer 23

Question 24

B-thal

Clinical presentation of minor, intermedia, major

Answer 24

Question 25

Thalassemia Anemic symptoms

Answer 25

Question 26

Extremedullary hematopoiesis Symptoms

Answer 26

Question 27

Iron overload Symptoms

Answer 27

Question 28

Thalassemia Cardiopulmonary complications

Answer 28

Question 29

Thalassemia Musculoskeletal complications

Answer 29

Question 30

Thalassemia Ix

Answer 30

Question 31

Thalassemia Mx

Answer 31

Question 32

Thalassemia Treatment for iron overload Refractory to transfusion Mx

Answer 32

Question 33

Thalassemia Disease monitoring

Answer 33

Question 34

Familial anemia Ddx

Answer 34

Question 35

Familial anemia Hx P/E

Answer 35

Question 36

Aplastic anemia Primary and secondary causes

Answer 36

Question 37

Aplastic anemia Pathogenesis S/S

Answer 37

Question 38

Aplastic anemia Ix

Answer 38

Question 39

Aplastic anemia Severity grading Prognosis

Answer 39

Question 40

Aplastic anemia Mx

Answer 40

Question 41

Fanconi anemia Cause S/S Dx Mx Prognosis

Answer 41

Question 42

Dyskeratosis congenita Cause S/S Dx Mx Prognosis

Answer 42

Question 43

Diamond blackfan anemia Cause S/S Dx Mx Prognosis

Answer 43

Question 44

Ddx acquired hemolytic anemia

Answer 44

Question 45

Intravascular hemolysis Causes Pathogenesis Clinical presentation

Answer 45

Question 46

Extravascular hemolysis Causes Pathogenesis Clinical presentation

Answer 46

Question 47

Hemolytic anemia Ix

Answer 47

Question 48

Red cell membrane Proteins for cytoskeleton

Answer 48

Question 49

Hereditary spherocytosis Pathogenesis Clinical presentation

Answer 49

Question 50

Hereditary spherocytosis Dx Mx

Answer 50

Question 51

Pyruvate kinase deficiency Cause S/S Dx Mx

Answer 51

Question 52

G6PD Pathogenesis

Answer 52

Question 53

G6PD Clinical presentation

Answer 53

Question 54

G6PD Triggers of hemolysis

Answer 54

Question 55

G6PD hemolysis Ix Mx

Answer 55

Question 56

Hemoglobin defects Ddx

Answer 56

Question 57

Hemostasis Physiology

Answer 57

Question 58

Coagluation cascade

Answer 58

Question 59

PT, aPTT function

Answer 59

Question 60

Clotting disorder Vasculature causes

Answer 60

Question 61

Congenital platelet defects

Answer 61

Question 62

Acquired platelet defects

Answer 62

Question 63

Coagulation defects

Answer 63

Question 64

Differentiate platelet vs coagluation defect

Answer 64

Question 65

Clotting defect Hx

Answer 65

Question 66

Clotting disorder P/E

Answer 66

Question 67

Clotting disorder Ix

Answer 67

Question 68

Thrombocytopenia Ddx

Answer 68

Question 69

Thrombocytopenia Ix

Answer 69

Question 70

Thrombocytopenia Mx

Answer 70

Question 71

ITP Causes

Answer 71

Question 72

ITP Pathogenesis

Answer 72

Question 73

ITP Clinical presentation

Answer 73

Question 74

ITP Dx

Answer 74

Question 75

ITP Mx 1st line therapy

Answer 75

Question 76

ITP 2nd line therapy/ Mx of refractory ITP

Answer 76

Question 77

Clotting profile Metrics Typical range

Answer 77

Question 78

Clotting Factor deficiency tests

Answer 78

Question 79

Ddx isolated prolonged PT, aPTT

Answer 79

Question 80

Ddx prolonged PT and aPTT Ddx bleeding with normal clotting profile

Answer 80

Question 81

Approach to isolated prolonged PT/ aPTT

Answer 81

Question 82

Approach to prolonged PT + aPTT

Answer 82

Question 83

Hemophilia Cause Severity grading

Answer 83

Question 84

Hemophilia Clinical presentation

Answer 84

Question 85

Hemophilia Ix

Answer 85

Question 86

Hemophilia Mx

Answer 86

Question 87

Hemophilia Indications for prophylactic vs on-demand factor replacement

Answer 87

Question 88

Hemophilia Specific tx for types of bleeding

Answer 88

Question 89

Hemophilia Refractory to factor replacement Mx

Answer 89

Question 90

VWD Types Pathogenesis

Answer 90

Question 91

VWD S/S

Answer 91

Question 92

VWD Ix Dx

Answer 92

Question 93

VWD Mx

Answer 93

Question 94

Thrombophilia Ddx

Answer 94

Question 95

Antithrombin deficiency Clinical features Tx

Answer 95

Question 96

Protein C/S deficiency Clinical presentation Tx

Answer 96

Question 97

Workup for unexplained thrombosis

Answer 97

Question 98

DIC Pathogenesis

Answer 98

Question 99

MAHA, TMA, DIC Definition

Answer 99

Question 100

DIC Causes

Answer 100

Question 101

DIC Clinical presentation Cx

Answer 101

Question 102

DIC

Answer 102

Question 103

DIC Ix

Answer 103

Question 104

DIC Mx

Answer 104