Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

LAT prep by TAC (laboratory animal technician) > Hard facts > Flashcards

Hard facts Flashcards

1
Q

What test did the OECD (Organization for Economic Cooperation and Development) guidlines replace?

A

LD 50 Test

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Subacute multidose toxicity studies are how long?

A

28 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Subchronic multidose toxicity studies are how long?

A

13 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Chronic multidose toxicity studies are how long? (3 time frames)

A

26, 38 or 52 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How many test groups are usually in a study?

A

4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How many rodents or non-rodents are in a subacute study?

A

10 rodents, or 2-3 non-rodents per sex (so 20 rodents or 4-6 non-rodents total)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is a teratogen?

A

A substance that damages the fetus.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Reproductive studies tend to have 3 segments. What do these segments test?

A

Seg. 1: reproductive toxicity in male and female.
Seg.2: Fetal toxicity.
Seg. 3: Toxicity in newborn pups

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

1g= mL (only true w/ water)

A

1mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is a pyrogen?

A

A substance that creates a fever.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Blood from what organism is used to detect bacterial toxins (pyrogens) in LAL test?

A

Horseshoe crab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is a LAL test and what does it do?

A

Limulus Amebocyte Test. Clumps in the pesence of toxin.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Nude mice lack (__) cells because the don’t have a (__).

A

t-cells, thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

T-cells usually help with what type of immunity?

A

Cell-mediated immunity. they attack viruses, tumors, help w/ making antigen as well.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Athymic Rats don’t have (__) and therefore their immunity resembles (__).

A

Thymus, nude mice.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

(_____) Mice lack both T and B Cells. This results in no cell-mediated immunity, antibodies or long-term immunity.

A

SCID (severe combined immunodeficiency disorder)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Asplenic mice lack what?

A

a spleen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What strains of mice lack B-cells and are used to study heredity defects?

A

CBAN/N, XID

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Biege mice lack what? (2 things)

A

Natural killer cells and cytotoxic properties.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Reporter proteins are:

A

Floresent probes used in bioluminescent technologies. Usually used w/ mice and zebra fish.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

B Cells Produce which cells that make antibodies?

A

Plasma cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What are polyclonal antibodies?

A

Copies of multiple antibodies produced by one plasma cell. Each antibody is a “clone”.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What three animals are commonly used in antibody research?

A

Rabbits, sheep and goats

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What are the 2 most common needle curvatures?

A

1/2 and 3/8 circle.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What is the difference between conventional and reverse cutting needles?

A

Conventional cutting needles have the cutting edge on the inside of the curve, reverse cutting needles have the cutting edge on the outside of the needle.

26
Q

Which needle combines the cutting and reverse cutting edges at the tip of the needle?

A

Tapered needle.

27
Q

What is the most common scapel handle, also known as the ribbed-back?

A

Bard-parker scapel handle

28
Q

Most commonly used blade that fits #3 handle

A

Size 10 blade

29
Q

A size 20 blade is similar to what other blade in shape? What handle does it fit?

A

Similar in shape to size 10blade. Fits #4 handle

30
Q

What blade has a small cutting blade for fine/delicate tissue and mouse surgery? What handle does it fit?

A

size 15 blade,# 3 handle

31
Q

What blade has a straight edge w/ a fine point? Fits a #3 handle.

A

Size 11 blade

32
Q

What are the 5 routes of infection?

A

1) inhalation, 2) skin (cuts/infection), 3) mucous membranes, 4)mouth/ingestion, 5) maternal tranmission

33
Q

What is the term for removing embryos surgically from one mouse and implanting in a non-infected serrogate?

A

Rederivation

34
Q

Hamsters can be non-symptomatic carriers of what disease?

A

Lymphocytic choriomeningitits

35
Q

Herpes is fatal to what primate species?

A

Owl monkeys and marmosats. (herpes is *epidemic in people)

36
Q

Epizootic is:

A

a sudden disease outbreak that affects a large number of animals.

37
Q

Enzootic is: (comparible to endemic in ppl)

A

if a disease commonly occurs in multiple members of the population.

38
Q

Clinical Disease is:

A

When the animal has visible signs.

39
Q

No visible signs of a disease is:

A

Subclinical

40
Q

A Paracute disease is:

A

sudden and severe

41
Q

An acute disease is:

A

rapid onset and short duration

42
Q

A Chronic disease is:

A

gradual onset and long duration

43
Q

Pasturellosis is a ___ disease (infection) commonly seen in ___ that can’t be cured.

A

chronic, rabbits

44
Q

Active Immunity

A

Response of the immune system in which Lymphocytes and antibodies are produced in reaction against an invading antigen.

45
Q

Passive Immunity

A

From mother.

46
Q

What is Transient Ataxia?

A

Ataxia brought on by tranquilizers or anesthetics.

47
Q

Puritis

A

persistant itching

48
Q

Enteritis

A

Swollen intestines leading to diahrea

49
Q

Mating unrelated animals (mice) in a closed colony results in a “sterilized” genetic composition called what?

A

Outbred stocks

50
Q

What are examples of outbred mice, supplied by Swiss Webster?

A

CD-1, ICR, CFW

51
Q

At least 20 consecutive strains of brother/sister mating, which results in ____ strains of mice (animals).

A

Inbread

52
Q

Examples of common inbred strains (6 listed)

A

BalbB/c (albino), C3H (agouti), C57BL/6 (black), DBA (brown, oldest strain), FVB (albino), 129 (light bellied agouti).

53
Q

Hybrid Strains are a mix of 2 strains. If you mate 1 pair of a female C57BL/6, with a male C3H, what will the offsprings formula be?

A

B6C3F1

54
Q

A mucus plug only stays in place for__.

A

24hrs

55
Q

Weight gain in mice starts how many days into gestation?

A

13 days

56
Q

Post-partum estrus can start how quickly after parturition in mice?

A

14-28 hrs

57
Q

Mouse estrus is how often?

A

every 4-5 days

58
Q

Mice gestation is how long?

A

19-21 days

59
Q

Mice are born altricial. What does this mean?

A

They are hairless, with eyes and ears closed.

60
Q

When do mice first open their eyes/ears and grow fur?

A

10-14 days after birth.

61
Q

From BC1-BC5, which is obese and which is emaciated?

A

Emaciated BC1-Obese BC5

62
Q

What are the key pts in each BC rating?

A

BC1- prominante skeleton and vetebral segments, BC2-vetebral column evident w/ pelvis palpable, BC3-well conditioned w/ palpable skeleton, BC4- ,BC5- smooth and bulky body, bone structur “dissapear”.

LAT prep by TAC (laboratory animal technician) (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions