Hardass Immuno

Question 1

IL-12 stims

Answer 1

Th1

Question 2

IL-4 stims

Answer 2

Th2

Question 3

TGF-B and IL-6 stim

Answer 3

Th17

Question 4

Naive T cell adhesion molecules

Answer 4

LFA-1 and VLA-4

Question 5

T cell chemokine receptor

Answer 5

CCR7

Question 6

DCs maturation response to T cells

Answer 6

Up-regulate CCR7
Increase expression of CD80 (B7)
Travel to secondary lymph tissue

Question 7

What cell can activate naive t cells

Answer 7

DC

Question 8

First signal for T cell activation (T cell response)

Answer 8

Increase CD40L

Increase CD28

Question 9

First signal for T cella ctivation (APC response)

Answer 9

Increase CD40
Increase CD80 (B7)

Question 10

What makes a T cell anergic

Answer 10

Not activated b/c co-stim igands are not working

Question 11

What does binding of IL-2 to IL-2R do

Answer 11

Promote T proliferation and differentiation

Question 12

Cytokines for Th1

Answer 12

IFN-y and IL-12

Question 13

Cytokines for Th2

Answer 13

IL-4, 5, 13

Question 14

Cytokines for Th17

Answer 14

TGF-B, IL-17 and IL-22

Question 15

Cytokines for Tfh

Answer 15

IL-21

Question 16

Cross presentation is necessary for ___ activation

Answer 16

CD8

Question 17

Once activated T cells start expressing

Answer 17

CTLA-4

Question 18

Novel TF for T reg CD4 cells

Answer 18

FOXp3

Question 19

Treg secrete the cytokines

Answer 19

IL-10 and TGF-B

Question 20

What is needed for CTLs to respond to an antigen

Answer 20

Nothing

Question 21

Th1 secrete

Answer 21

IL-2 and IFN-y

Question 22

Th1 function

Answer 22

Activate DC, macro and NK

Question 23

Th1 TF

Answer 23

T-bet

Question 24

Th2 activated by

Answer 24

IL-4

Question 25

Th2 responds to

Answer 25

Allergens and helminths

Question 26

Th2 TF

Answer 26

GATA-3

Question 27

Th2 secretes

Answer 27

IL-4, 5 ,13

Question 28

Th2 aids in stimulating what Ig

Answer 28

IgE

Question 29

Th1 vs Th2 macro activation

Answer 29

``` 1= classical 2= alternative ```

Question 30

Is Th1 or Th1 better against intracell microbes

Answer 30

Th1

Question 31

Th17 responds to

Answer 31

Il-1 and IL-6 | Bacteria and fungus

Question 32

Th17 TF

Answer 32

ROR y t

Question 33

Th17 secretes

Answer 33

IL-17 and 22

Question 34

Th17 main function

Answer 34

Barrier function and neutrophil activation

Question 35

CCR7 on T cell binds

Answer 35

CCL29 or 21

Question 36

LFA-1 on T cell binds

Answer 36

Icam-1

Question 37

Is L-selectin in neutrophil or endothelial

Answer 37

Neutrophil

Question 38

What Th cells enhance CTL response

Answer 38

Th1 via IL-2

Question 39

2 methods of CTL killing

Answer 39

Cytotoxins or FasL/Fas (CD95)

Question 40

Cytokines that enhance NK cells

Answer 40

IFN-a, IFN-B and IL-12

Question 41

What do ADCC recognize

Answer 41

IgG or IgE

Question 42

Cytokines required for Memory T cell survival

Answer 42

IL-7 and IL-15