Head and neck cancer Flashcards Preview

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Flashcards in Head and neck cancer Deck (16)
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1

Risk factors

Tobacco
Alcohol
Viruses - EBV, HPV
Betel nut chewing
Hardwood

2

HPV cancers - where do they present

Tonsils
Base of tongue

3

HPV cancers - transmission

Sexual

4

HPV cancers - prognosis

Good

5

Most common type

Squamous cell carcinoma

6

Clinical features

Symptoms persist for at least 3 weeks
- sore throat
- hoarseness
- stridor
- dysphagia
- odynophagia
- lump in neck
- unilateral ear pain
- voice change

7

Examination

Changes in colour/texture of mouth
Palpate any abnormalities (firm - usually cancerous)
Examine lymph nodes
Feel thyroid

8

Investigations

Nasal endoscopy
FNA - to get a sample of cells
Ultrasound
CT
MRI

9

Management

Analgesia
Surgery
Chemotherapy
Radiotherapy
Nutritional support

10

Nasopharyneal cancers in young people are usually caused by???

EBV

11

Nasopharyngeal cancers in older people are usually caused by???

Smoking
Alcohol

12

Small tumour with big lymph nodes

HPV

13

HPV makes E6/E7 which disrupts the p53 pathway?

E6

14

HPV makes E6/E7 which disrupts Rb?

E7

15

Young people who were previously fit and healthy are most likely to get which cancer?

HPV related squamous cell carcinoma

16

HPV related squamous cell carcinoma does not respond well to chemotherapy / radiotherapy. True or false?

False
- it does respond well to this treatment