Headache Lecture Powerpoint Flashcards

1
Q

Headache epidemiology

A

90-95% will experience in lifetime, 90% of headaches fall into either tension, migraine, or cluster type with tension being most prevalent in population

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2
Q

Pain sensitive structures of head (7)

A
  • Arteries (circle of willis, cerebral arteries, meningial arteries, veins/dural sinuses)
  • Scalp
  • neck muscles
  • cranial nerves V, VII, IX, X
  • sinus mucosa
  • teeth
  • skin
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3
Q

Primary vs secondary headaches

A

Primary include migraine, tension type, and cluster as well as other categories vs secondary which are caused by potentially serious underlying disease such as a space occupying mass, vascular lesion, infection, etc.

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4
Q

Red flags that point toward a worrisome secondary headache (6)

A
  • Fixed neurological deficits
  • extremely abrupt onset
  • papilledema (increased intracranial pressure)
  • New onset of headache in patients <5 or >50 years old
  • signs of infection (nuchal rigidity for example)
  • altered state of consciousness
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5
Q

Aneurysms presentation and treatment

A
  • A secondary cause of headache that is often asymptomatic until rupture occurs, sees the ballooning out of a blood vessel with a berry appearance, if rupture sudden onset headache with severe “worst headache of life” resulting in stiff neck, fever, nausea, vomiting, with several neurological signs dependent on location of aneurysm
  • need immediate treatment such as surgical clipping
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6
Q

Meningitis definition, presentation, and diagnosis

A
  • Inflammation of the meninges that is a 2ndary cause of headache
  • Usually presents with stiff neck, early prodromoal illness fever may be present and later focal neurological signs develop
  • need CT to rule out mass then immediate lumbar puncture
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7
Q

Cervicogenic headache definition, diagnosis, and treatment

A
  • 2ndary cause of headache that is from referred pain from cervical spine or neck soft tissue pathology
  • best diagnosed by resolution of headache following diagnostic blockade of a cervical structure or its nerve supply
  • pain resolves within 3 months after treatment of causative lesion
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8
Q

Idiopathic intracranial hypertension/pseudomotor cerebri presentation, diagnosis, and treatment

A
  • Characterized by transient headache with visual loss or decrease for no apparent reason usually affecting young obese women of childbearing years, increased risk with use of estrogen and vit A
  • Diagnosis made by obtaining lumbar puncture with opening pressure
  • Weight loss is curative in many cases, acetazolamide (diamox) is used often alongside optic nerve sheath decompression to treat
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9
Q

Low pressure headache definition, presentation, and treatment

A
  • Headache that resolves or greatly decreases in supine and returns when upright position is maintained
  • very intense pain with vomiting that can be spontaneous (sometimes rarely brought on by sneeze or cough) or related to a spinal procedure such as lumbar puncture (slow leakage causing decreased pressure)
  • can be treated by placing blood patch at the site of the leak to cure it completely
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10
Q

Temporal arteritis/giant cell arteritis definition, presentation, diagnosis, treatment, comorbidity

A
  • Inflammation of temporal artery causing head pain close to temporal region
  • associated with jaw claudication almost exclusively in patients over 60
  • typically ESR is elevated, temporal artery biopsy is gold standard for diagnosis
  • treat with steroids to prevent vision loss
  • 50% also develop polymyalgia rheumatica
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11
Q

Temporal arteritis is often the first presenting condition in a patient that will develop….

A

…..polymyalgia rheumatica

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12
Q

Polymyalgia rheumatica

A

Inflammatory disease in patients older than 65 characterized by muscle pain and stiffness, particularly in the shoulders

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13
Q

Medication overuse headache definition, prevalence among men vs women, treatment (what should be delayed in using)

A
  • Headache from frequent and regular use of any analgesic (opiod, acetaminophen, etc), a consequence of regular overuse for more than 3 months
  • more common in women than men
  • withdrawal of overused medication is treatment of choice while bridge therapy used during withdrawal to provide symptomatic relief, prophylactic medication used to treat suspected primary headache disorder should only be initiated after withdrawal
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14
Q

Sinus headache misdiagnosis, presentation

A
  • Although commonly diagnosed by physicians and patients, acute and chronic sinusitis is an uncommon cause for recurrent headaches, many times these patients are actually having migraine headaches
  • usually bilaterally pressure like or dull sensation, not usually associated with nausea vomiting or photophobia unlike migraines
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15
Q

Migraine epidemiology

A

Affects 12% of population with women>men, most common in 30-39 year old range, tends to run in families

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16
Q

Migraine mech of action

A

(proposed)

  • Cortical spreading depression (self propagating wave of neuronal and glial cell depolarization across cerebral cortex)
  • aura caused by this
  • activation of the afferent components of trigem nerve that triggers the release of inflammatory and pain producing substances that can be significantly disabling
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17
Q

Migraine

A

Episodic disorder characterized by recurrent attacks that occur over the course of several hours or days resulting in severe headache, nausea, photophobia, phonophobia that progresses thru 4 phases typically (prodrome, aura, headache, postdrome)

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18
Q

Prodrome phase of migraine

A

Occurs in 60% of people about 24-48 hrs prior to the headache, symptoms can include euphoria, depression, irritability, food cravings, constipation, neck stiffness, and increased yawning

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19
Q

Aura phase of migraine

A

25% of patients experience gradual development of symptoms, seeing visual changes (most common) - shapes, bright lines, etc. Auditory changes such as tinnitus, hearing noises, somatosensory changes such as burning, pain, parasthesia, or motor symptoms such as jerking or repetitive movements, as well as loss of vision, hearing, feeling, or ability to move part of body often mischaracterized as stroke

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20
Q

Migraine aura without headache

A

Variant of migraine headache where the patient, often occurring later in life with history of migraines, get stereotyped spells of aura only, important to exlude TIA or seizure

21
Q

Headache phase of migraine

A

Usually unilateral, throbbing or pulsatile quality, nausea and sometimes vomiting, photophobia or phonophobia, usually seek relief by lying down in dark quiet room, 4 hours to several days in length if untreated

22
Q

Postdrome phase of migraine

A

Once the headache throbbing resolves, sometimes sudden head movmeent transiently causes pain, feels drained or exhausted, feel mild elation or euphoria, depression, irritability, food cravings, etc

23
Q

Common precipitating factors of migraines (6)

A
  • emotional stress
  • dehydration or alcohol
  • weather
  • odors
  • lights
  • food
24
Q

Migraine diagnosis

A

Clinical, meeting diagnostic criteria, neuroimaging is NOT necessary in most patients

25
Q

Treatment principle for migraine

A

Acute and preventative therapies are available, not everyone needs preventative but everyone needs acute treatment

26
Q

Acute treatment of migraine medications (3)

A
  • Simple analgesics such as tylenol, motrin, or otc meds such as excedrine migraine
  • Triptans (sumatriptan (imitrex), rizatriptan (maxalt), eletriptan (relpax))
  • ergot derivatives
27
Q

Triptans are contraindicated in patients that have these conditions (3)

A
  • uncontrolled hypertension
  • history of stroke
  • heart attack history
28
Q

Migraine headache cocktail and its 4-5 components

A

Emergency department medication for abortive treatment of a migraine composed of a triptan, fluids, and antiemetic med (dopamine receptor antagonist) alongside diphenhydramine (benadryl) to prevent dystonic reaction and sometimes dexamethasone to reduce risk of early headache recurrance

29
Q

Prophylaxis treatment against migraines (9)

A
  • lifestyle modifications
  • Physical therapy
  • Nutritional supplements
  • TCA’s
  • B blockers
  • antiepileptics
  • C-GRP antagonist such as erenumab (aimovig) antibody injection given once a month
  • Butterbur
  • Magnesium and riboflavin
30
Q

Botox relation to migraines

A

Approved for treatment of chronic migraine

31
Q

Tension type headache epidemiology, characteristics, and pathophysiology

A
  • Most common type of primary headache in general population that usually affects women more than men,
  • is bilateral and characterized by pressing/tightening pain not as severe or pounding or with nausea
  • unknown pathophysiology but theorized to be multifactorial
32
Q

Tension type headache classification (3)

A
  • Episodic: 1 day a month
  • Frequent: 1-14 days a month
  • Chronic: 15 or more days per month
33
Q

Guideline to avoid medication overuse in treating tension type headaches

A

Combine with caffeine for simple analgesics and limit treatment 9 days per month and a max of 2 doses per treatment day

34
Q

Tension type headache treatment (1) and which 2 are not recommended

A
  • Most common reason OTC analgesics purchased

- Triptans and muscle relaxants are not recommended

35
Q

Cluster headaches epidemiology

A

100/100,000 people, more males than females, called suicide headache

36
Q

Cluster headaches are part of a group of headache entities called….

A

…Trigeminal autonomic cephalgias

37
Q

Cluster headaches pathophysiology

A

-not understood, increasing evidence of familial risk

38
Q

Cluster headaches clinical presentation (4)

A
  • Severe orbital, supraorbital, or temporal pain
  • restless and agitation
  • unilateral with associated unilateral autonomic symptoms (ptosis, lacrimation, rhinorrhea)
  • circadian periodicity 15-180 min in length up to 8 attacks per day
39
Q

Cluster headaches diagnostic studies (2)

A
  • IS advised to do neuroimaging:
  • MRI with or without contrast
  • CT
40
Q

Cluster headaches acute treatment options (2)

A
  • O2 therapy via nonrebreather is mainstay***

- subQ sumatriptan

41
Q

Treatment of choice for preventative treatment of cluster headaches (1)

A

-Verapamil (ca2+ channel blocker)

42
Q

Important history questions when inquiring about primary cause of headache (5)

A
  • visual changes
  • menstrual related
  • trauma history
  • history of high blood pressure
  • headache diary?
43
Q

Every patient presenting with headache requires a….

A

….fundoscopic exam

44
Q

When is neuroimaging necessary for headache? (5)

A
  • abnormal neurological exam
  • recent significant change in pattern, frequency, or severity of headaches
  • progressive worsening of headaches
  • onset after 40
  • history of seizures
45
Q

When is lumbar puncture necessary for headache? (2)

A
  • First unusually severe headache

- co-occurrence with fever, confusion, or seizures

46
Q

Headache diagnostic studies (4)

A
  • Brain MRI
  • CT of head
  • ESR (for temporal arteritis)
  • Lumbar puncture
47
Q

Acetazolamide (diamox) drug class

A

Carbonic anhydrase inhibitor

48
Q

Triptan mech of action

A
  • Activates vascular serotonin 5HT1 receptors producing vasoconstriction
  • inhibit release of vasoactive peptides, promote vasoconstriction, and block pain pathways in brainstem
49
Q

Ergot derivatives mech of action

A

-constrict cranial and peripheral blood vessels