Healing and repair CC

Question 1

What causes scurvy?

Answer 1

Vit C deficiency

Question 2

Describe the mechanism that causes the problems related to scurvy

Answer 2

Inadequate Vit C dependent hydroxylation of procollagen alpha chains–>Less crosslinking so defective helix formation

Question 3

How does scurvy present

Answer 3

Unable to heal wounds
Tooth loss
Old scars reopen

Question 4

What is the underlying mechanism behind Ehlers-Dnalos Syndrome?
What is the presentation of this?

Answer 4

Defective conversion of procollagen to tropocollagen

Skin hyperextensible, thin, fragile
Prediposition to joint dslocation

Question 5

Osteogenesis Imperfecta
What is it?
Clinical manifastations?

Answer 5

Too little T1 collagen–>Too little bone tissue

Severe deformation of long bones
Blue sclera
Dental abnormalities
Hearing impairment

Question 6

ALport syndrome
What is it
Causes dysfunction of what? And how does it present?

Answer 6

T4 collagen abnormal
Dysfunction of Glomerular basement membrane, Cochlea of ear and lens of eye
Presents with haematuria
Eventually leads to renal failure

Question 7

What is a keloid scar?

Answer 7

A overgrowth of scar tissue, beyond the borders of the original scar

Question 8

How does a keloid scar differ to a hypertrophic scar

Answer 8

Hypertrophic scar characterised by raised fibrous lesions. Don’t expand beyond the boundaries of the original lesions
Keloid scar is an overgrowth of dense fibrous tissue beyond the borders of the original wound

Question 9

Which group of people are particularly at risk of keloid scar formation

Answer 9

Afro Caribbean peoples