Heart Failure and Hypertrophy (Chronic Cardiac Adaptation) Flashcards Preview

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Flashcards in Heart Failure and Hypertrophy (Chronic Cardiac Adaptation) Deck (13):
1

What MHC isoforms are found in the heart?

α and β MHC isoforms

2

T or F: different MHC heterodimers have distinct ATPase activity

True, and functional properties

3

How is the expression of α and β MHC regulated?

transcriptionally regulated

4

What changes are seen in phenotypically distinct models of cardiac hypertrophy?

Myosin isoform and ATPase shifts

5

What specific changes are seen in pathological hypertrophy?

Decrease in ATPase
and increase ββ MHC

6

What specific changes are seen in physiological hypertrophy?

Increase in ATPase
and in αα MHC

7

What causes pathological hypertrophy?

Aortic valve stenosis
chronic hypertension

8

What causes physiological hypertrophy?

Chronic exercise
Pregnancy

9

T of F: In response to stress, both the quantity and the quality of the contractile elements is altered

True

10

The phenotypic adaptions may involve what?

both transcriptional and post-translational modifications (Most imp point in this lecture)

11

T or F: The functional adaptations can lead to ventricular dysfunction over time

True

12

What are the cellular mechanisms behind left ventricular hypertrophy (LVH)?

-Likely increase in Ca current via L-type Ca channel
-Reduced SR pump fxn (↑ PLB/SERCA2 ratio)
-Impaired myofilament relaxation
-Altered (increased) cytosolic calcium and new steady-state

13

What is the proposed transcriptional regulation of gene expression in cardiac cells?

Calcineuron dephosphorylates NFAT allowing passage to nucleus where it acts as a transcription factor